Magnesium lithospermate B ameliorates renal cortical microperfusion in rats
文献类型：期刊论文
| 作者 | Chen, CG; Wang, YP
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2006-02 |
| 卷号 | 27期号:2页码:217-222 |
| 关键词 | magnesium lithospermate B hemodynamics renal blood flow renal cortical microperfusion |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2006.00225.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To investigate the effects of magnesium lithospermate B (MLB) isolated from Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics in Sprague-Dawley rats. Methods: MLB (10, 30, and 60 mg/kg) was injected intravenously and renal blood flow (RBF), renal cortical microperfusion (RCM), and systemic hemodynamic function parameters including heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and maximal velocity of pressure increase (dp/dt(max)) were measured for 45 min after administration. Results: Intravenous MLB at doses of 10, 30, and 60 mg/kg increased RCM significantly, but had no obvious effects on RBF or systemic hemodynamics. The effect of MLB on RCM reached its peak 15 min after injection and returned to baseline after 45 min. Up to 60 mg/kg MLB increased RCM by 62.4%+/- 20.2% (changes from baseline, P < 0.01), whereas RBF (3.7%+/- 9.7% vs baseline) and renal vascular resistance (-1.4%+/- 9.1% vs baseline) did not obviously change. Conclusion: These results indicate that MLB ameliorates renal microcirculation in a dose-dependent manner, which may be related to the renoprotective effects of MLB. |
| WOS关键词 | NITRIC-OXIDE ; VASCULAR-RESISTANCE ; SALVIA-MILTIORRHIZA ; OXYGEN RADICALS ; FAILURE ; PROSTAGLANDINS ; SUPEROXIDE ; RESPONSES ; KIDNEY ; INJURY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2658942 |
| WOS记录号 | WOS:000234794700013 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273670]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, YP |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, CG,Wang, YP. Magnesium lithospermate B ameliorates renal cortical microperfusion in rats[J]. ACTA PHARMACOLOGICA SINICA,2006,27(2):217-222. |
| APA | Chen, CG,&Wang, YP.(2006).Magnesium lithospermate B ameliorates renal cortical microperfusion in rats.ACTA PHARMACOLOGICA SINICA,27(2),217-222. |
| MLA | Chen, CG,et al."Magnesium lithospermate B ameliorates renal cortical microperfusion in rats".ACTA PHARMACOLOGICA SINICA 27.2(2006):217-222. |
入库方式： OAI收割
来源：上海药物研究所
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