Synthesis of novel bone-targeted agents for treatment of osteoporosis
文献类型：期刊论文
| 作者 | Wang, JB; Yang, CH ; Ding, HS; Yan, XM; Wu, XH; Xie, YY
|
| 刊名 | INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
 |
| 出版日期 | 2006-01 |
| 卷号 | 45期号:1页码:318-321 |
| 关键词 | bone osteoporosis bisphosphonates raloxifene |
| ISSN号 | 0376-4699 |
| 文献子类 | Article |
| 英文摘要 | Novel bone-targeted agents have been designed and synthesized by the combination of raloxifene and bisphosphonates. The antiosteoporosis effect has been evaluated by bone mineral density (BMD) obtained from ovariectomized (OVX) mice in vivo. The results indicate that the compounds 8 and 9 not only prevent ovariectomy induced loss of bone but also enhance BMD to 7.09 and 12.59% compared to sham-operated control, respectively. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000235016300016 |
| 出版者 | NATL INST SCIENCE COMMUNICATION |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273733]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xie, YY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, JB,Yang, CH,Ding, HS,et al. Synthesis of novel bone-targeted agents for treatment of osteoporosis[J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY,2006,45(1):318-321. |
| APA | Wang, JB,Yang, CH,Ding, HS,Yan, XM,Wu, XH,&Xie, YY.(2006).Synthesis of novel bone-targeted agents for treatment of osteoporosis.INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY,45(1),318-321. |
| MLA | Wang, JB,et al."Synthesis of novel bone-targeted agents for treatment of osteoporosis".INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 45.1(2006):318-321. |
入库方式： OAI收割
来源：上海药物研究所
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