Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats
文献类型：期刊论文
| 作者 | Liang, X; Wang, YZ; Liu, J ; Luo, XT; Ye, Y; Zhu, XZ
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2005-12-12 |
| 卷号 | 78期号:4页码:413-420 |
| 关键词 | paconiflorin (PF) middle cerebral artery occlusion (MCAO) tongue protrusion (TP) water maze |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2005.04.069 |
| 文献子类 | Article |
| 英文摘要 | In the present study, the effects of paeoniflorin (PF), a characteristic monoterpene glucoside isolated from Paeoniae Radix, on cerebral infarction, neurological symptoms, tongue protrusion (TP) and performance in the water maze were examined at the chronic stage (4 weeks) of transient cerebral ischemia using a rat middle cerebral artery occlusion (MCAO) model. One-day (10 mg/kg, twice, s.c.) or seven-day (2.5 -10 mg/kg, twice a day, s.c.) injection of PF significantly reduced the infarct volume as well as ameliorated the deficits in neurological symptoms caused by transient MCAO at chronic stage. Transient MCAO also induced impairments in TP and performance in the water maze. Treatment with PF was able to reverse or alleviate these impairments. These results indicate that PF may be effective for treatment of stroke. (c) 2005 Elsevier Inc. All rights reserved. |
| WOS关键词 | RADIAL MAZE PERFORMANCE ; LONG-TERM POTENTIATION ; MAJOR CONSTITUENT ; TONGUE PROTRUSION ; PEONY ROOT ; ADENOSINE ; ISCHEMIA ; HIPPOCAMPUS ; STROKE ; INVOLVEMENT |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000233368900012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273756]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, X,Wang, YZ,Liu, J,et al. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats[J]. LIFE SCIENCES,2005,78(4):413-420. |
| APA | Liang, X,Wang, YZ,Liu, J,Luo, XT,Ye, Y,&Zhu, XZ.(2005).Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats.LIFE SCIENCES,78(4),413-420. |
| MLA | Liang, X,et al."Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats".LIFE SCIENCES 78.4(2005):413-420. |
入库方式： OAI收割
来源：上海药物研究所
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