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A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
文献类型：期刊论文
| 作者 | Zhou, WL; Wu, JM; Wu, QL; Wang, JX; Zhou, Y ; Zhou, R; He, PI; Li, XY; Yang, YF; Zhang, Y
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2005-11 |
| 卷号 | 26期号:11页码:1352-1358 |
| 关键词 | artemisinin non-steroidal anti-inflammatory agents SM735 immuno-suppressive activity |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2005.00232.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To study the immunosuppressive activity of SM735 {[3-(12-beta-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal antiinflammatory drug structure, with the aim of finding potential immunosuppressive agents. Methods: Concanavalin A (ConA), lipopolysaccharide (LPS), and mixed lymphocyte reaction (MLR), were used to induce the proliferation of splenocytes, and [H-3]-thymidine-incorporation was used to evaluate the proliferation of splenocytes. Cytokine production was promoted with ConA, LPS, or PMA plus ionomycin, and was detected with the enzyme-linked immunosorbent assay. Dinitrofluorobenzene (DNFB) and sheep red blood cells (SRBC) were used to induce delayed-type hypersensitivity and quantitative hemolysis of SRBC (QHS) mouse models, as criteria for the evaluation of in vivo immune activity. Results: SM735 strongly inhibited the proliferation of splenocytes induced by ConA, LPS, or MLR, with IC50 values of 0.33 mu mol/L, 0.27 mu mol/L, and 0.51 mu mol/L, respectively. When compared with a CC50 value of 53.1 mu mol/L, SM735 had a favorable safety range. SM735 dose-dependently inhibited proinflammatory cytokine production [including interleukins (IL)-12, interferon (IFN)-gamma and IL-6] induced by LPS or PMA plus ionomycin. Upon ConA stimulation, SM735 suppressed IFN-gamma in a dose-dependent manner, but did not affect IL-2 secretion. SM735 also strongly suppressed both T-cell-mediated delayed-type hypersensitivity (DTH) and B-cell-mediated QHS reactions. Conclusion: SM735 had strong immunosuppressive activity in vitro and in vivo, suggesting a potential role for SM735 as an immunosuppressive agent, and established the groundwork for further research on SM735. |
| WOS关键词 | QINGHAOSU ARTEMISININ ; ANTIMALARIAL-DRUG ; MICE ; TOLERANCE ; RESPONSES ; IMMUNITY ; TRANSPLANTATION ; CYCLOSPORINE ; PROTEINS ; CELLS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2165405 |
| WOS记录号 | WOS:000233209800012 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273774]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, JP |
| 作者单位 | 1.Chinese Acad Sci, Lab Immunopharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Lab Synth Chem, Grad Sch, State Key Lab Drug Res,Shanghai Inst Mat Med,Inst, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, WL,Wu, JM,Wu, QL,et al. A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo[J]. ACTA PHARMACOLOGICA SINICA,2005,26(11):1352-1358. |
| APA | Zhou, WL.,Wu, JM.,Wu, QL.,Wang, JX.,Zhou, Y.,...&Zuo, JP.(2005).A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo.ACTA PHARMACOLOGICA SINICA,26(11),1352-1358. |
| MLA | Zhou, WL,et al."A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo".ACTA PHARMACOLOGICA SINICA 26.11(2005):1352-1358. |
入库方式： OAI收割
来源：上海药物研究所
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