Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
文献类型：期刊论文
| 作者 | Ding, HS; Zhang, C; Wu, XH; Yang, CH ; Zhang, XW; Ding, J; Xie, YY
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2005-11-01 |
| 卷号 | 15期号:21页码:4799-4802 |
| 关键词 | indole alpha-methylene-gamma-lactones AKT-mTOR signaling pathway kinase inhibitors |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2005.07.050 |
| 文献子类 | Article |
| 英文摘要 | In an effort to generate novel anticancer agents, a series of hybrids of alpha-methylene-gamma-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results indicate that substitutes on the gamma-position of lactones have a rather significant influence on inhibition activities. (c) 2005 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TRANSLATION |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000232465900030 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273777]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, CH |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci,Grad Sch, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, HS,Zhang, C,Wu, XH,et al. Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(21):4799-4802. |
| APA | Ding, HS.,Zhang, C.,Wu, XH.,Yang, CH.,Zhang, XW.,...&Xie, YY.(2005).Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,15(21),4799-4802. |
| MLA | Ding, HS,et al."Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15.21(2005):4799-4802. |
入库方式： OAI收割
来源：上海药物研究所
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