Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A(1) receptor in a manner different from its classical agonists
文献类型：期刊论文
| 作者 | Liu, DZ; Xie, KQ; Ji, XQ; Ye, Y ; Jiang, CL; Zhu, XZ
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| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2005-10 |
| 卷号 | 146期号:4页码:604-611 |
| 关键词 | paeoniflorin neuroprotective effect adenosine A(1) receptor transient cerebral ischemia permanent cerebral ischemia cardiovascular side effect |
| ISSN号 | 0007-1188 |
| DOI | 10.1038/sj.bjp.0706335 |
| 文献子类 | Article |
| 英文摘要 | 1 The effects of paeoniflorin (PF), a compound isolated from Paeony radix, on neurological impairment and histologically measured infarction volume following transient and permanent focal ischemia were examined in Sprague-Dawley rats. 2 In transient ischemia model, rats were subjected to a 1.5-h occlusion of the middle cerebral artery (MCA). The administration of PF (2.5 and 5 mg kg(-1), s.c.) produced a dose-dependent decrease in both neurological impairment and the histologically measured infarction volume. Similar results were also obtained when PF (2.5, 5, and 10 mg kg(-1), s.c.) was given in permanent ischemia model. 3 The neuroprotective effect of PF (10mg kg(-1), s.c.) was abolished by pretreatment of DPCPX (0.25 mg kg(-1), s.c.), a selective adenosine A, receptor (AIR) antagonist. 4 PF (10, 40, and 160 mg kg(-1), i.v.) had no effect on mean arterial pressure (MAP) and heart rates (HR) in the conscious rat. Additionally, PF (10(-3) mol l(-1)) had no effect on noradrenaline- (NA-) or high K+ concentration-induced contractions of isolated rabbit primary artery. 5 In competitive binding experiments, PF did not compete with the binding of [H-3]DPCPX, but displaced the binding of [H-3]NECA to the membrane preparation of rat cerebral cortex. This binding manner was distinguished from the classical A(1)R agonists. 6 The results demonstrated that activation of A(1)R might be involved in PF-induced neuroprotection in cerebral ischemia in rat. However, PF had no 'well-known' cardiovascular side effects of classical A(1)R agonists. The results suggest that PF might have the potential therapeutic value as an anti-stroke drug. |
| WOS关键词 | ARTERY OCCLUSION ; WHITE ADIPOCYTES ; WISTAR RATS ; IN-VIVO ; MODULATION ; PERMANENT ; RELEASE ; NEURONS ; BINDING ; PROTEIN |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000232785200017 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273794]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, DZ,Xie, KQ,Ji, XQ,et al. Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A(1) receptor in a manner different from its classical agonists[J]. BRITISH JOURNAL OF PHARMACOLOGY,2005,146(4):604-611. |
| APA | Liu, DZ,Xie, KQ,Ji, XQ,Ye, Y,Jiang, CL,&Zhu, XZ.(2005).Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A(1) receptor in a manner different from its classical agonists.BRITISH JOURNAL OF PHARMACOLOGY,146(4),604-611. |
| MLA | Liu, DZ,et al."Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A(1) receptor in a manner different from its classical agonists".BRITISH JOURNAL OF PHARMACOLOGY 146.4(2005):604-611. |
入库方式： OAI收割
来源：上海药物研究所
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