Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons
文献类型：期刊论文
| 作者 | Gao, ZB ; Hu, GY
|
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2005-09-14 |
| 卷号 | 1056期号:1页码:68-75 |
| 关键词 | antioxidant hippocampus neuroprotection trans-resveratrol voltage-activated K+ current |
| ISSN号 | 0006-8993 |
| DOI | 10.1016/j.brainres.2005.07.013 |
| 文献子类 | Article |
| 英文摘要 | The red wine ingredient traps-resveratrol was found to exert potent neuroprotective effects in different in vivo and in vitro models. Thus far, the mechanisms underlying the neuroprotection were attributed mainly to its antioxidant properties. The aim of this study was to investigate the actions of traps-resveratrol on voltage-gated K+ channels, which have been implicated in neuronal apoptosis. Superfusion of traps-resveratrol reversibly inhibited both the delayed rectifier (I-K) and fast transient K+ current (I-A) in rat dissociated hippocampal neurons with IC50 values of 13.6 +/- 1.0 mu M and 45.7 +/- 7.5 mu M, respectively. The inhibition on IK had a slow onset, was neither voltage dependent nor use dependent. Traps-resveratrol (30 mu M) shifted the steady-state inactivation curve of IK to the hyperpolarizing direction by 20 mV and slowed down its recovery from inactivation. The inhibition on I-A was similar to that on IK, but voltage dependent. Superfusion of transresveratrol (30 mu M) shifted the steady-state activation curve of IA to the depolarizing direction by 17 mV. Intracellular application of transresveratrol (30 mu M) was ineffective. Based on the comparable effective concentrations, the inhibition of voltage-activated K+ currents by trans -resveratrol may contribute to its neuroprotective effects. (c) 2005 Elsevier B.V. All rights reserved. |
| WOS关键词 | CA1 PYRAMIDAL NEURONS ; PROTEIN-KINASE-C ; OXIDATIVE STRESS ; NEURODEGENERATIVE DISORDERS ; FOREBRAIN ISCHEMIA ; K+ CURRENTS ; APOPTOSIS ; NEUROTOXICITY ; ENHANCEMENT ; CHANNELS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000231937300008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273804]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 神经药理学研究国际科学家工作站 |
| 通讯作者 | Hu, GY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Media, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, ZB,Hu, GY. Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons[J]. BRAIN RESEARCH,2005,1056(1):68-75. |
| APA | Gao, ZB,&Hu, GY.(2005).Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons.BRAIN RESEARCH,1056(1),68-75. |
| MLA | Gao, ZB,et al."Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons".BRAIN RESEARCH 1056.1(2005):68-75. |
入库方式： OAI收割
来源：上海药物研究所
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