Total synthesis of (R)-(+)-Kavain via (MeCN)(2)PdCl2-catalyzed isomerization of a cis double bond and sonochemical Blaise reaction
文献类型：期刊论文
| 作者 | Wang, FD; Yue, JM
|
| 刊名 | SYNLETT
 |
| 出版日期 | 2005-08-19 |
| 期号 | 13页码:2077-2079 |
| 关键词 | kavain total synthesis (MeCN)(2)PdCl2-catalyzed isomerization cis double bond sonochemical Blaise reaction |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-2005-871953 |
| 文献子类 | Article |
| 英文摘要 | From the chiral source 2,3-O-isopropylidene-D-glyceraldehyde 2, the natural product (R)-(+)-kavain 1a was efficiently synthesized in a total yield of 25% via (MeCN)(2)PdCl2-catalyzed isomerization of the cis double bond of an olefin as the key step and sonochemical Blaise reaction. The chiral center adjacent to the cis double bond was retained without protection of the free allylic hydroxy during the isomerization process. |
| WOS关键词 | PIPER METHYSTICUM ; (+/-)-KAVAIN ; KAVALACTONES ; (+)-KAVAIN ; EXTRACT ; KAWAIN ; ALPHA ; DIENE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000231457700022 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273816]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, JM |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, FD,Yue, JM. Total synthesis of (R)-(+)-Kavain via (MeCN)(2)PdCl2-catalyzed isomerization of a cis double bond and sonochemical Blaise reaction[J]. SYNLETT,2005(13):2077-2079. |
| APA | Wang, FD,&Yue, JM.(2005).Total synthesis of (R)-(+)-Kavain via (MeCN)(2)PdCl2-catalyzed isomerization of a cis double bond and sonochemical Blaise reaction.SYNLETT(13),2077-2079. |
| MLA | Wang, FD,et al."Total synthesis of (R)-(+)-Kavain via (MeCN)(2)PdCl2-catalyzed isomerization of a cis double bond and sonochemical Blaise reaction".SYNLETT .13(2005):2077-2079. |
入库方式： OAI收割
来源：上海药物研究所
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