Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro
文献类型：期刊论文
| 作者 | Xie, YL; Ding, HS; Qian, LH; Yan, XM; Yang, CH ; Xie, YY
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2005-07-01 |
| 卷号 | 15期号:13页码:3267-3270 |
| 关键词 | bisphosphonates osteoporosis osteoclast osteoblast |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2005.04.062 |
| 文献子类 | Article |
| 英文摘要 | In an effort to generate novel anti-osteoporosis agents, new bisphosphonates with various benzoyl groups on side chains have been synthesized and evaluated for activities on both bone resorption and bone formation in vitro. Several candidates showed distinct dual activities: promoting bone formation and inhibiting bone resorption. (c) 2005 Elsevier Ltd. All rights reserved. |
| WOS关键词 | OSTEOPOROSIS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000230062300019 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273841]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xie, YY |
| 作者单位 | 1.Columbia Univ, Dept Med, New York, NY 10032 USA 2.Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, YL,Ding, HS,Qian, LH,et al. Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(13):3267-3270. |
| APA | Xie, YL,Ding, HS,Qian, LH,Yan, XM,Yang, CH,&Xie, YY.(2005).Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,15(13),3267-3270. |
| MLA | Xie, YL,et al."Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15.13(2005):3267-3270. |
入库方式： OAI收割
来源：上海药物研究所
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