中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

文献类型:期刊论文

作者Wang, FD; Yue, JM
刊名EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2005-06-13
期号12页码:2575-2579
关键词dihydroxykavain mitsunobu reaction natural products sonochemistry total synthesis
ISSN号1434-193X
DOI10.1002/ejoc.200400833
文献子类Article
英文摘要Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(+)-dihydrokavain (1a) is demonstrated for the first time by total synthesis from a chiral source. Its opposite enantiomer, (R)-(-)-dihydrokavain (1b), was also synthesized after inversion of the chiral center in a Mitsunobu reaction. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
WOS关键词ASYMMETRIC-SYNTHESIS ; ALPHA
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000229947200016
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/273853]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Yue, JM
作者单位Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Wang, FD,Yue, JM. A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2005(12):2575-2579.
APA Wang, FD,&Yue, JM.(2005).A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(12),2575-2579.
MLA Wang, FD,et al."A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .12(2005):2575-2579.

入库方式: OAI收割

来源:上海药物研究所

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