Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects
文献类型：期刊论文
| 作者 | Tong, YG; Zhang, XW; Tian, F; Yi, YH; Xu, QZ; Li, L ; Tong, LJ; Lin, LP; Ding, J
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| 刊名 | INTERNATIONAL JOURNAL OF CANCER
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| 出版日期 | 2005-05-10 |
| 卷号 | 114期号:6页码:843-853 |
| 关键词 | philinopside A receptor tyrosine kinase tumor angiogenesis |
| ISSN号 | 0020-7136 |
| DOI | 10.1002/ijc.20804 |
| 文献子类 | Article |
| 英文摘要 | Philinopside A is a novel sulfated saponin isolated from the sea cucumber, Pentacta quadrangulari. The effects of philinopside A on angiogenesis and tumor growth were assessed in a series of models in vitro and in vivo. Our results demonstrated that philinopside A significantly inhibited the proliferation, migration and tube formation of human microvascular endothelial cells (HMECs) in a dose-dependent manner, with average IC50 values of 1.4 +/- 0.17, 0.89 +/- 0.23 and 0.98 +/- 0.19 mu M, respectively. Rat aortas culture assay provides a close imitation of in vivo angiogenesis process and 2-10 mu M philinopside A suppressed the formation of new microvessels in cultured rat aortas. Philinopside A 2-10 nmol/egg obviously inhibited angiogenesis in chick embryo chorioallantoic membrane assay. In addition, philinopside A manifested strong anti-tumor activities both in vitro and in vivo. Through immunofluorescent analysis, we found the compound reduced mouse sarcoma 180 tumor volume by inducing apoptosis of tumor and tumor-associated endothelial cells. An examination of the effects of philinopside A on the angiogenesis-related receptor tyrosine kinases (RTKs) showed that philinopside A broadly inhibited all tested RTKs, including vascular endothelial growth factor (VEGF) receptor, fibroblast growth factor (FGF) receptor-1, platelet-derived growth factor (PDGF) receptor-beta and epithelial growth factor (EGF) receptor, with IC50 values ranging from 2.6-4.9 mu M. These results suggest that philinopside A is a promising anti-cancer agent that possesses dual cytotoxic and anti-angiogenic effects that were at least partly due to its inhibitory effects on RTKs. (c) 2005 Wiley-Liss, Inc. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; RENAL-CELL CARCINOMA ; TYROSINE KINASE INHIBITORS ; IN-VITRO ANGIOGENESIS ; CHEMOTHERAPEUTIC-AGENTS ; TUMOR ANGIOGENESIS ; TUBE FORMATION ; PHASE-II ; RECEPTOR ; CANCER |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000228338700001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273872]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Ding, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Div Anti Tumor Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, YG,Zhang, XW,Tian, F,et al. Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects[J]. INTERNATIONAL JOURNAL OF CANCER,2005,114(6):843-853. |
| APA | Tong, YG.,Zhang, XW.,Tian, F.,Yi, YH.,Xu, QZ.,...&Ding, J.(2005).Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects.INTERNATIONAL JOURNAL OF CANCER,114(6),843-853. |
| MLA | Tong, YG,et al."Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects".INTERNATIONAL JOURNAL OF CANCER 114.6(2005):843-853. |
入库方式： OAI收割
来源：上海药物研究所
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