Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola
文献类型：期刊论文
| 作者 | Chen, Y ; Zhang, YX; Li, MH; Zhao, WM; Shi, YH; Miao, ZH; Zhang, XW; Lin, LP; Ding, J
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| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| 出版日期 | 2005-04-22 |
| 卷号 | 329期号:4页码:1334-1342 |
| 关键词 | 11,11'-dideoxyverticillin HUVEC angiogenesis VEGF anticancer |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2005.02.115 |
| 文献子类 | Article |
| 英文摘要 | The fungus Shiraia bambusicola yields the phytochemical 11,11'-dideoxyverticillin, which has been shown to possess potent anti-cancer activity both in vitro and in vivo. In this study, we reveal that 11,11'-dideoxyverticillin has anti-angiogenic activities and explore the potential mechanisms for this effect. Treatment with 11,11'-dideoxyverticillin inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) with IC50 values of 0.17 +/- 0.05 mu M for VEGF-stimulated cells and 0.39 +/- 0.08 mu M for serum-stimulated cells. 11,11'-Dideoxyverticillin also antagonized the antiapoptotic effects of VEGF on serum-deprived HUVECs, inhibited VEGF-induced HUVEC migration in vitro, and blocked serum-induced HUVEC tube formation. Moreover, 11,11'-dideoxyverticillin completely blocked VEGF-induced microvessel sprouting from Matrigel-embedded rat aortic rings and vessel growth in Matrigel plugs in mice. In addition, 11,11'-dideoxyverticillin decreased VEGF secretion by MDA-MB-468 breast cancer cells, and significantly suppressed VEGF-induced tyrosine phosphorylation of Flt-1 and KDR/Flk-1. This inhibition of receptor phosphorylation was correlated with a marked decrease in VEGF-triggered pERK activation and a dramatic increase in pP38 MAPK, but no apparent change in pAkt. Together, these findings strongly suggest that 11,11'-dideoxyverticillin is a structurally novel angiogenesis inhibitor. (c) 2005 Elsevier Inc. All rights reserved. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; IN-VITRO ANGIOGENESIS ; SIGNAL-TRANSDUCTION ; PROTEIN-KINASE ; TUBE FORMATION ; CELL SURVIVAL ; INHIBITION ; RECEPTORS ; PROLIFERATION ; ACTIVATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000227886300024 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273883]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Div Antitumor Pharamcol,Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Y,Zhang, YX,Li, MH,et al. Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,329(4):1334-1342. |
| APA | Chen, Y.,Zhang, YX.,Li, MH.,Zhao, WM.,Shi, YH.,...&Ding, J.(2005).Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,329(4),1334-1342. |
| MLA | Chen, Y,et al."Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 329.4(2005):1334-1342. |
入库方式： OAI收割
来源：上海药物研究所
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