Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms
文献类型：期刊论文
| 作者 | Fan, Y; Hu, JF; Li, J ; Yang, Z; Xin, XL; Wang, J; Ding, J; Geng, MY
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2005-02-21 |
| 卷号 | 374期号:3页码:222-226 |
| 关键词 | oligosaccharide AOSC scopolamine water maze oxidative stress neurotoxicity apoptosis |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2004.10.063 |
| 文献子类 | Article |
| 英文摘要 | In this study we evaluated the effect of a novel, marine-derived, acidic oligosaccharide on scopolamine-induced amnesia in rats using the Morris water maze test. The results show that 30-day administration of this oligosaccharide, referred to as acidic oligosaccharide sugar chain (AOSC), to rats attenuates memory impairment by scopolamine, as evaluated by shortened escape latency, swimming distance, and increased swimming time of rats with memory impairment induced by scopolamine in the quadrant where the platform is placed. The data additionally suggest that an appropriate dose of scopolamine, a traditional muscarinic receptor antagonist, elevates oxidative damage in brain, characterized by inactivation of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and consequently, inhibition of ATPase in the hippocampus and cerebral cortex. AOSC ameliorates oxidative injuries caused by scopolamine by increasing the activities of SOD, GSH-Px, and ATPase. Further investigation by flow cytometry revealed that AOSC significantly reduces the overloading of intracellular free calcium ion ([Ca2+](i)), thus suppressing apoptosis induced by H2O2 in human neuroblastoma SH-SY5Y cells. These findings suggest that AOSC can induce cognitive improvement via its antioxidant activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | CALCIUM DYSREGULATION ; OXIDATIVE STRESS ; PC12 CELLS ; WATER-MAZE ; APOPTOSIS ; INHIBITION ; INJURY ; MODEL ; TASK ; MICE |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000226896700015 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273906]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, J |
| 作者单位 | 1.Chinese Acad Med Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 2.Ocean Univ China, Dept Pharmacol, Marine Drug & Food Inst, Qingdao 266003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Y,Hu, JF,Li, J,et al. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms[J]. NEUROSCIENCE LETTERS,2005,374(3):222-226. |
| APA | Fan, Y.,Hu, JF.,Li, J.,Yang, Z.,Xin, XL.,...&Geng, MY.(2005).Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.NEUROSCIENCE LETTERS,374(3),222-226. |
| MLA | Fan, Y,et al."Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms".NEUROSCIENCE LETTERS 374.3(2005):222-226. |
入库方式： OAI收割
来源：上海药物研究所
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