Swietenia mahagony extract shows agonistic activity to PPAR gamma and gives ameliorative effects on diabetic db/db mice
文献类型：期刊论文
| 作者 | Li, DD; Chen, JH; Chen, Q; Li, GW; Chen, J ; Yue, JM; Chen, ML; Wang, XP; Shen, JH; Shen, X
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2005-02 |
| 卷号 | 26期号:2页码:220-222 |
| 关键词 | Swietenia mahagony diabetes mellitus peroxisome proliferator-activated receptor gamma yeast-two hybrid |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2005.00027.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To search the peroxisome proliferator-activated receptor gamma (PPARgamma) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of SmE on diabetic db/db mice. Methods: The PPARgamma agonistic activity of SmE was screened by yeast-two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDST8.8W software. Results: By using the clinical drug rosiglitazone as a positive control, it was found that the PPARgamma agonistic activity of SmE at a concentration of 50 mug/L was approximately half that of 35.7 mug/L (0.1 mumol/L) of rosiglitazone. At the dose of 1000 mg/kg, SmE remarkably decreased the blood glucose concentration of db/db mice from (15.26 +/- 2.98) to (7.58 +/- 2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group (P<0.01). Conclusion: SmE shows agonistic activity to PPARgamma and can ameliorate the blood glucose levels of diabetic db/db mice. SmE may be thus used as a potential agent for diabetes therapy. |
| WOS关键词 | PROLIFERATOR-ACTIVATED RECEPTORS ; DISCOVERY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1918429 |
| WOS记录号 | WOS:000226942000015 |
| 出版者 | SHANGHAI INST MATERIA MEDICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273913]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第三研究室 |
| 通讯作者 | Shen, JH |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Shanghai Inst Biol Sci, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China 2.Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China 3.Zhejiang Coll Tradit Chinese Med, Anim Expt Ctr, Hangzhou 310053, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, DD,Chen, JH,Chen, Q,et al. Swietenia mahagony extract shows agonistic activity to PPAR gamma and gives ameliorative effects on diabetic db/db mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(2):220-222. |
| APA | Li, DD.,Chen, JH.,Chen, Q.,Li, GW.,Chen, J.,...&Jiang, HL.(2005).Swietenia mahagony extract shows agonistic activity to PPAR gamma and gives ameliorative effects on diabetic db/db mice.ACTA PHARMACOLOGICA SINICA,26(2),220-222. |
| MLA | Li, DD,et al."Swietenia mahagony extract shows agonistic activity to PPAR gamma and gives ameliorative effects on diabetic db/db mice".ACTA PHARMACOLOGICA SINICA 26.2(2005):220-222. |
入库方式： OAI收割
来源：上海药物研究所
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