Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa
文献类型：期刊论文
| 作者 | Zhan, ZJ; Fan, CQ; Ding, J ; Yue, HM
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2005-02-01 |
| 卷号 | 13期号:3页码:645-655 |
| 关键词 | novel daphnane-type diterpenoids Daphne genkwa inhibitory activity against endothelium cell HMEC cytotoxic activities |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2004.10.054 |
| 文献子类 | Article |
| 英文摘要 | Twelve highly oxygenated novel daphnane-type diterpenoids genkwanines A-L (1-12), together with four known diterpenes (13-16). were isolated from the bud of Daphne genkwa, a well-known traditional Chinese medicine (TCM). The new structures were elucidated on the basis of spectral methods, especially 2D NMR spectra (HMQC, HMBC, NOESY). Inhibitory activity against endothelium cell HMEC proliferation and cytotoxic activities against two tumor cell lines were assessed for all the compounds 1-16, and found to be significant and structure related. A number of compounds showed very potent cytotoxic activities against two tumor cell lines at the IC50 levels of 0.15-8.40 muM, and most interestingly five of the compounds 4, 8, 10, 13, and 14 exhibited strong activity to inhibit the endothelium cell HMEC at the IC50 levels of 2.90-15.0 muM. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SYNAPTOLEPIS-KIRKII ; ANTITUMOR AGENTS ; SKIN IRRITANTS ; ORTHO-ESTERS ; PRINCIPLES ; THYMELAEACEAE ; CONSTITUENTS ; AFRICANA ; CANCER ; FAMILY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000226676800006 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273915]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, HM |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhan, ZJ,Fan, CQ,Ding, J,et al. Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2005,13(3):645-655. |
| APA | Zhan, ZJ,Fan, CQ,Ding, J,&Yue, HM.(2005).Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa.BIOORGANIC & MEDICINAL CHEMISTRY,13(3),645-655. |
| MLA | Zhan, ZJ,et al."Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa".BIOORGANIC & MEDICINAL CHEMISTRY 13.3(2005):645-655. |
入库方式： OAI收割
来源：上海药物研究所
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