Effect of Feitai on bleomycin-induced pulmonary fibrosis in rats
文献类型：期刊论文
| 作者 | Gong, LK ; Li, XH; Wang, H; Zhang, L; Chen, FP; Cai, Y; Qi, XM; Liu, LL; Liu, YZ; Wu, XF
|
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2005-01-15 |
| 卷号 | 96期号:3页码:537-544 |
| 关键词 | Feitai pulmonary fibrosis bleomycin collagen |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2004.09.046 |
| 文献子类 | Article |
| 英文摘要 | The current therapeutic approaches for pulmonary fibrosis, which is characterized by fibroblast proliferation and extracellular matrix remodeling. are unsatisfactory. Feitai, consisting of several herbs, is a folk formula for pulmonary tuberculosis therapy in China. To investigate the effects of Feitai on pulmonary fibrosis, Feitai was administered orally to bleomycin (BLM)-treated rats, and the lung toxicity effects were evaluated according to inflammatory cell count, protein concentration, and lactate dehydrogenase (LDH) activity in the bronchoalveolar lavage fluid (BALF), malondialdehyde level and hydroxyproline content in lung tissue 28 days post-BLM. Serial sections of the lung were stained with hematoxylin and eosin (HE) and Masson trichrome, respectively. The degree of fibrosis was assessed quantitatively using LEICA QWin image analyzer. Results showed that Feitai inhibited BLM-induced lung fibrotic lesions in a dose-dependent manner as reflected by decreased the lung hydroxyproline content and lung fibrosis fraction 28 days after BLM instillation. Treatment with Feitai also significantly ameliorated the BLM-induced lung toxicity effects detected in BALF and lung tissue. The effects in vitro on WI-38 human lung fibroblast cell line showed that Feitai significantly reduced the cell proliferation and transforming growth factor (TGF)-beta stimulated type I collagen synthesis. These results strongly demonstrate that Feitai may be useful in the treatment of pulmonary fibrosis. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | INDUCED LUNG FIBROSIS ; N-ACETYLCYSTEINE ; MICE ; INJURY ; ATTENUATION ; SURFACTANT ; PROTECTION ; TOXICITY ; DAMAGE ; MODEL |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000226427600025 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273943]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ren, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Branch, Grad Sch, Shanghai 200031, Peoples R China 3.Shanghai Pulm Hosp, Shanghai 200043, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, LK,Li, XH,Wang, H,et al. Effect of Feitai on bleomycin-induced pulmonary fibrosis in rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2005,96(3):537-544. |
| APA | Gong, LK.,Li, XH.,Wang, H.,Zhang, L.,Chen, FP.,...&Ren, J.(2005).Effect of Feitai on bleomycin-induced pulmonary fibrosis in rats.JOURNAL OF ETHNOPHARMACOLOGY,96(3),537-544. |
| MLA | Gong, LK,et al."Effect of Feitai on bleomycin-induced pulmonary fibrosis in rats".JOURNAL OF ETHNOPHARMACOLOGY 96.3(2005):537-544. |
入库方式： OAI收割
来源：上海药物研究所
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