Neuroprotective effects of huperzine A - A natural cholinesterase inhibitor for the treatment of Alzheimer's disease
文献类型：期刊论文
| 作者 | Wang, R; Tang, XC
|
| 刊名 | NEUROSIGNALS
 |
| 出版日期 | 2005 |
| 卷号 | 14期号:1-2页码:71-82 |
| 关键词 | huperzine A Alzheimer's disease acetylcholinesterase cholinesterase inhibitor cognitive enhancer neuroprotection oxidative stress beta-amyloid amyloid precursor protein cerebral ischemia apoptosis apoptotic-related gene mitochondria glutamate NMDA receptor potassium current |
| ISSN号 | 1424-862X |
| DOI | 10.1159/000085387 |
| 文献子类 | Review |
| 英文摘要 | Huperzine A (HupA), isolated from Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase. It has been found to reverse or attenuate cognitive deficits in a broad range of animal models. Clinical trials in China have demonstrated that HupA significantly relieves memory deficits in aged subjects, patients with benign senescent forgetfulness, Alzheimer's disease (AD) and vascular dementia (VD), with minimal peripheral cholinergic side effects compared with other AChEls in use. HupA possesses the ability to protect cells against hydrogen peroxide, beta-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53 and caspase-3, protect mitochondria, and interfere with APP metabolism. Antagonizing effects on NMDA receptors and potassium currents may contribute to the neuroprotection as well. It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. The therapeutic effects of HupA on AD or VD are probably exerted via a multi-target mechanism. Copyright (C) 2005 S. Karger AG, Basel. |
| WOS关键词 | RAT PHEOCHROMOCYTOMA CELLS ; AMYLOID PRECURSOR PROTEIN ; SPATIAL WORKING-MEMORY ; LONG-TERM POTENTIATION ; EXPERIMENTAL COGNITIVE IMPAIRMENT ; OXYGEN-GLUCOSE DEPRIVATION ; INDUCED OXIDATIVE INJURY ; RADIAL MAZE PERFORMANCE ; CORTICAL-NEURONS ; CEREBRAL-CORTEX |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000229790600007 |
| 出版者 | KARGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273967]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, R,Tang, XC. Neuroprotective effects of huperzine A - A natural cholinesterase inhibitor for the treatment of Alzheimer's disease[J]. NEUROSIGNALS,2005,14(1-2):71-82. |
| APA | Wang, R,&Tang, XC.(2005).Neuroprotective effects of huperzine A - A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.NEUROSIGNALS,14(1-2),71-82. |
| MLA | Wang, R,et al."Neuroprotective effects of huperzine A - A natural cholinesterase inhibitor for the treatment of Alzheimer's disease".NEUROSIGNALS 14.1-2(2005):71-82. |
入库方式： OAI收割
来源：上海药物研究所
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