Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats
文献类型：期刊论文
| 作者 | Liao, Y; Wang, R; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2004-12 |
| 卷号 | 25期号:12页码:1590-1596 |
| 关键词 | meclofenoxate brain ischemia free radicals maze learning TXB2 6-keto-PGF(1 alpha) Bax protein p53 protein |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of centrophenoxine (CPH, meclofenoxate) on chronic cerebral hypoperfusion induced deficits in rats. METHODS: Chronic hypoperfusion in rats was performed by permanent bilateral ligation of the common carotid arteries. Morris water maze was used to measure spatial memory performance. Spectrophotometrical techniques were used to assay SOD, GPx activities, MDA content, TXB2, and 6-keto-PGF(1alpha) levels. Morphological change was examined by HE staining. The expression of Bax and p53 protein were assayed by immunohistochemistry analysis. RESULTS: Chronic hypoperfusion in rats resulted in spatial memory impairments shown by longer escape latency and shorter time spent in the target quadrant. These behavioral dysfunction were accompanied by increase in SOD and GPx activities, the content of MDA, the levels of pro-inflammatory mediators (TXB2, 6-keto-PGF(1alpha)), overexpression of Bax and P53 protein, and delayed degeneration of neurons in cortex and hippocampus. Oral administration of CPH (100 mg/kg, once per day for 37 d) markedly improved the memory impairment, reduced the increase in antioxidant enzyme activities, MDA content and the levels of pro-inflammatory mediators to their normal levels, and attenuated neuronal damage. CONCLUSION: The abilities of CPH to attenuate memory deficits and neuronal damage after ischemia may be beneficial in cerebrovascular type dementia. |
| WOS关键词 | SUPEROXIDE-DISMUTASE ; BRAIN ACETYLCHOLINE ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; WISTAR RATS ; HYPOPERFUSION ; RADICALS ; BLOOD |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000225845200004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273979]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Y,Wang, R,Tang, XC. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats[J]. ACTA PHARMACOLOGICA SINICA,2004,25(12):1590-1596. |
| APA | Liao, Y,Wang, R,&Tang, XC.(2004).Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats.ACTA PHARMACOLOGICA SINICA,25(12),1590-1596. |
| MLA | Liao, Y,et al."Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats".ACTA PHARMACOLOGICA SINICA 25.12(2004):1590-1596. |
入库方式： OAI收割
来源：上海药物研究所
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