Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes
文献类型：期刊论文
| 作者 | Fu, Y; Zhu, ZT; Zhu, XZ; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2004-12 |
| 卷号 | 25期号:12页码:1597-1605 |
| 关键词 | berberine dopamine D1 receptors dopamine D2 receptors nucleus accumbens |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To investigate the possibility whether THPB-18 (l-12-shloroscoulerine) possesses the D(1) agonist-D(2) antagonist action on meso-accumbens-mPFC DA system. METHODS: Single unit spontaneous firing activity was recorded in the nucleus accumbens (NAc) neurons of naive and unilateral-6-hydroxydopamine (6-OHDA)-lesioned Sprague-Dawley rats. The effects of drugs applied intravenously or iontophoretically were determined by the change of firing rates. RESULTS: Under normal conditions, the systemic administration of THPB-18 produced a decrease-increase biphasic firing pattern in the NAc neurons during cumulative doses. High dose of THPB-18 was capable of reversing the inhibition induced by both D(2) agonist LY171555 and D(1)/D(2) agonist APO on NAc firing activity. Spiperone pretreatment could not block the high dose of THPB-18-induced firing rate increase, which was reversed by the D, selective antagonist SCH23390. The tested NAc neurons were effectively inhibited by iontophoretically applied THPB-18 in 90 % of 6-OHDA-lesioned rats, while THPB-18 caused variable effects on the firing of NAc neurons in the neurons of unlesioned rats. The inhibitory effect of THPB-18 was blocked by iontophoretic application of SCH23390, but not D2 antagonist spiperone. CONCLUSION: Similar to I-stepholidine, THPB-18 also possesses the "D(1) agonistic-D(2) antagonistic" dual action on the VTA-NAc DA system. |
| WOS关键词 | DOPAMINE-RECEPTORS ; PREFRONTAL CORTEX ; L-STEPHOLIDINE ; (-)-STEPHOLIDINE ; SCHIZOPHRENIA ; RATS ; D-1 ; PATHOPHYSIOLOGY ; ANTAGONISTS ; MODULATION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000225845200005 |
| 出版者 | SHANGHAI INST MATERIA MEDICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273980]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Jin, GZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Y,Zhu, ZT,Zhu, XZ,et al. Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes[J]. ACTA PHARMACOLOGICA SINICA,2004,25(12):1597-1605. |
| APA | Fu, Y,Zhu, ZT,Zhu, XZ,&Jin, GZ.(2004).Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes.ACTA PHARMACOLOGICA SINICA,25(12),1597-1605. |
| MLA | Fu, Y,et al."Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes".ACTA PHARMACOLOGICA SINICA 25.12(2004):1597-1605. |
入库方式： OAI收割
来源：上海药物研究所
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