Studies on chemical constituents of the soft coral Scleronephthya sp. from the South China Sea
文献类型：期刊论文
| 作者 | Yan, XH; Guo, YW ; Zhu, XZ; Mollo, E; Cimino, G
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| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2004-10 |
| 卷号 | 24期号:10页码:1233-1238 |
| 关键词 | soft coral Scleronephthya sp. chemical constituent |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | Thirteen compounds have been isolated from Et2O soluble fraction of the soft coral Scleronephthya sp. The structures of these compounds were characterized by H-1 NMR, C-13 NMR, HMQC, HMBC, H-1-H-1 COSY, EIMS and compared with the data reported in literature as pregna-20-en-3beta-O-acetate (1), pregna-5, 20-dien-3beta-O-acetate (2), pregna-20-en-3-one (3), 1, 2-epoxypregna-20-en-3-one (4), pregna-1, 20-dien-3-one (5), pregna-1-en-3one-20-S-methyl-21-O-acetate (6), pregna-1-en-3-one-20beta-O-acetate (7), cholest-1-en-3,22-dione (8), cholest-1, 24-en-3-one-22,23-diol (9), O-methylisogrifolin (10), (1R,3S,4S,7E,11E)-3alpha,4alpha-epoxycembra-7,11,15-triene (11), (3R,3R')-astaxanthin (12) and 6-bromoindole-3-carboxylic acid (13), respectively. Among them, compounds 4, 6 and 10 were first isolated from natural sources. Spectroscopic data of compounds 6, 7 and 10 were first reported, and their 13 C NMR data were assigned by 2D NMR. This paper also discussed the possible biosynthesis of compounds 1 similar to 7. Compounds 6 and 7 show inhibitory activity to HELA cell line, and their IC50 values are 3.3 and 6.3 mol/L, respectively. Compound 7 also shows inhibitory activity to BEL7402 and HL-60 cel line, and its IC50 value is 3.1 and 0.26 mol/L, respectively. Compound 11 shows inhibitory activity to COX-2 with IC50 of 0.455 mol/L. |
| WOS关键词 | STEROIDS ; PRODUCTS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| WOS记录号 | WOS:000224369300011 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274011]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yan, XH |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.CNR, Ist Chim Biomol, I-80078 Puzzuoli, NA, Italy |
| 推荐引用方式 GB/T 7714 | Yan, XH,Guo, YW,Zhu, XZ,et al. Studies on chemical constituents of the soft coral Scleronephthya sp. from the South China Sea[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2004,24(10):1233-1238. |
| APA | Yan, XH,Guo, YW,Zhu, XZ,Mollo, E,&Cimino, G.(2004).Studies on chemical constituents of the soft coral Scleronephthya sp. from the South China Sea.CHINESE JOURNAL OF ORGANIC CHEMISTRY,24(10),1233-1238. |
| MLA | Yan, XH,et al."Studies on chemical constituents of the soft coral Scleronephthya sp. from the South China Sea".CHINESE JOURNAL OF ORGANIC CHEMISTRY 24.10(2004):1233-1238. |
入库方式： OAI收割
来源：上海药物研究所
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