Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients
文献类型：期刊论文
| 作者 | Zeng, R; Yang, RF; Shi, MD; Jiang, MR; Xie, YH; Ruan, HQ; Jiang, XS; Shi, L; Zhou, H ; Zhang, L
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| 刊名 | JOURNAL OF MOLECULAR BIOLOGY
 |
| 出版日期 | 2004-07-30 |
| 卷号 | 341期号:1页码:271-279 |
| 关键词 | SARS coronavirus 3a protein spike protein proteome |
| ISSN号 | 0022-2836 |
| DOI | 10.1016/j.jmb.2004.06.016 |
| 文献子类 | Article |
| 英文摘要 | Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TRANSMISSIBLE GASTROENTERITIS VIRUS ; PORCINE RESPIRATORY CORONAVIRUS ; SPIKE PROTEIN ; MEMBRANE-FUSION ; SEQUENCE ; GENOME ; IDENTIFICATION ; REVEALS ; ORF |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000222925100022 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274043]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Zeng, R |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Res Ctr Proteome Anal, Key Lab Proteon, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 4.Acad Mil Med Sci, Inst Microbial & Epidemiol, Beijing 100071, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Laboratorial Anim Ctr, Shanghai 201615, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Cell Resources Ctr, Cell Bank Type Culture Collect Comm, Shanghai 200031, Peoples R China 8.Shanghai Ctr Dis Control & Prevent, Shanghai 200336, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, R,Yang, RF,Shi, MD,et al. Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients[J]. JOURNAL OF MOLECULAR BIOLOGY,2004,341(1):271-279. |
| APA | Zeng, R.,Yang, RF.,Shi, MD.,Jiang, MR.,Xie, YH.,...&Wu, JR.(2004).Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients.JOURNAL OF MOLECULAR BIOLOGY,341(1),271-279. |
| MLA | Zeng, R,et al."Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients".JOURNAL OF MOLECULAR BIOLOGY 341.1(2004):271-279. |
入库方式： OAI收割
来源：上海药物研究所
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