Anticancer activity of methoxymorpholinyl doxorubicin (PNU 152243) on human hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Yuan, ST; Zhang, XW; Lu, LJ; Xu, CH; Yang, WY; Ding, J
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| 刊名 | ANTI-CANCER DRUGS
 |
| 出版日期 | 2004-07 |
| 卷号 | 15期号:6页码:641-646 |
| ISSN号 | 0959-4973 |
| 关键词 | anticancer activity doxorubicin hepatocellular carcinoma in vitro in vivo methoxymorpholinyl doxorubicin PNU 152243 |
| DOI | 10.1097/01.cad.0000132238.23050.f5 |
| 文献子类 | Article |
| 英文摘要 | Methoxymorpholinyl doxorubicin (PNU 152243) is a morpholinyl analog possessing a methoxymorpholinyl group at the 3' position of the sugar moiety, which, compared with doxorubicin, appears to be less cardiotoxic and more cytotoxic against multidrug-resistant tumor cells. In this study, we report the anticancer activity of PNU 152243 on human hepatocellular carcinoma (HCC) in vitro and in vivo. The average IC50 value of PNU was 0.08 muM. In contrast, the average IC50 values of adriamycin (ADM), 4'-epidoxorubicin (EDR), mitomycin C (MMC), cisplatin and vepesid (VP-16) were 0.96, 0.74, 2.81, 7.27 and 26.66 muM, respectively. PNU 152243 was 13.7,10.6, 40.1, 103.8 and 380.8 times more potent than ADM, EDR, MMC, cisplatin and VP-16 against HCC in vitro. In nude mice, the T/C (%) were 43.8 at the dose of 25 mug/kg and 41.2 at the dose of 50 mug/kg on BEL-7402 xenograft, the T/C (%) were 41.7 at the dose of 25 mug/kg and 54.6 at the dose of 50 mug/kg on Zip-177 xenograft. The results showed that PNU 152243 had growth inhibition of HCC in vitro and in vivo and may be useful in HCC chemotherapy. (C) 2004 Lippincott Williams Wilkins. |
| WOS关键词 | CELL-LINES ; ANTHRACYCLINE CARDIOTOXICITY ; ANTITUMOR-ACTIVITY ; TUMOR-CELLS ; RESISTANT ; DRUG ; CYTOTOXICITY ; ADRIAMYCIN ; FCE-23762 ; CANCER |
| WOS研究方向 | Oncology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| WOS记录号 | WOS:000222792600016 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274052]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, J |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, ST,Zhang, XW,Lu, LJ,et al. Anticancer activity of methoxymorpholinyl doxorubicin (PNU 152243) on human hepatocellular carcinoma[J]. ANTI-CANCER DRUGS,2004,15(6):641-646. |
| APA | Yuan, ST,Zhang, XW,Lu, LJ,Xu, CH,Yang, WY,&Ding, J.(2004).Anticancer activity of methoxymorpholinyl doxorubicin (PNU 152243) on human hepatocellular carcinoma.ANTI-CANCER DRUGS,15(6),641-646. |
| MLA | Yuan, ST,et al."Anticancer activity of methoxymorpholinyl doxorubicin (PNU 152243) on human hepatocellular carcinoma".ANTI-CANCER DRUGS 15.6(2004):641-646. |
入库方式： OAI收割
来源：上海药物研究所
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