Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis
文献类型：期刊论文
| 作者 | Tong, YG; Zhang, XW; Zhao, WM ; Zhang, YX; Lang, JY; Shi, YH; Tan, WF; Li, MH; Zhang, YW; Tong, LJ
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| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
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| 出版日期 | 2004-06-28 |
| 卷号 | 494期号:2-3页码:101-109 |
| 关键词 | Shiraiachrome A angiogenesis inhibitor arthritis receptor tyrosine kinase |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2004.04.053 |
| 文献子类 | Article |
| 英文摘要 | The Chinese folk medicine Shiraia bambusicola has long been utilized in the treatment of rheumatoid arthritis, a disease in which angiogenesis plays an important role. We report here the isolation of the compound Shiraiachrome A from S. bambusicola and the demonstration of its anti-angiogenic properties. We found that Shiraiachrome A significantly inhibited the proliferation, migration, and tube formation of human microvascular endothelial cells (HMEC) in a dose-dependent manner, with average IC50 values of 2.1 +/- 0.36, 1.97 +/- 0.44, and 1.65 +/- 0.59 muM, respectively. In addition, Shiraiachrome A inhibited the formation of new microvessels in a rat aorta culture model as well as in the chick embryo chorioallantoic membrane (CAM) assay. Investigation of the mechanism of action of Shiraiachrome A demonstrated that this compound suppressed the autophosphorylation of four receptor tyrosine kinases (RTKs), with IC50 values ranging from 2.2 to 4.3 muM. These results suggest that Shiraiachrome A inhibits angiogenesis by blocking growth factor-stimulated autophosphorylation of RTKs. These findings also indicate that Shiraiachrome A may be a potent therapeutic agent for angiogenesis-related diseases such as cancer, rheumatoid arthritis, and diabetic retinopathy. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; COLLAGEN-INDUCED ARTHRITIS ; RECEPTOR TYROSINE KINASES ; TUBE FORMATION ; FACTOR VEGF ; INHIBITION ; SUPPRESSION ; EXPRESSION ; MECHANISMS ; AGM-1470 |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000222398600003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274056]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Div Anti Tumor Pharmacol,State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai 201203, Peoples R China 3.St Louis Hosp Paris, INSERM, U553, Shanghai 200031, Peoples R China 4.Ruijin Hosp, Pols Sci Sino Francais Rech Sci Vivant, SIMM, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, YG,Zhang, XW,Zhao, WM,et al. Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,494(2-3):101-109. |
| APA | Tong, YG.,Zhang, XW.,Zhao, WM.,Zhang, YX.,Lang, JY.,...&Ding, J.(2004).Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis.EUROPEAN JOURNAL OF PHARMACOLOGY,494(2-3),101-109. |
| MLA | Tong, YG,et al."Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis".EUROPEAN JOURNAL OF PHARMACOLOGY 494.2-3(2004):101-109. |
入库方式： OAI收割
来源：上海药物研究所
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