Bioinformatics analysis of two-component regulatory systems in Staphylococcus epidermidis
文献类型：期刊论文
| 作者 | Qin, ZQ; Zhong, Y; Zhang, J ; He, YY; Wu, Y; Jiang, J; Chen, JM; Luo, XM; Qu, D
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| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2004-06 |
| 卷号 | 49期号:12页码:1267-1271 |
| 关键词 | Staphylococcus epidermidis two-component regulatory system histidine kinase response regulator bioinformatics drug target |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/03wc0384 |
| 文献子类 | Article |
| 英文摘要 | Sixteen pairs of two-component regulatory systems are identified in the genome of Staphylococcus epidermidis ATCC12228 strain, which is newly sequenced by our laboratory for Medical Molecular Virology and Chinese National Human Genome Center at Shanghai, by using bio-informatics analysis. Comparative analysis of the two-component regulatory systems in S. epidermidis and that of S. aureus and Bacillus subtilis shows that these systems may regulate some important biological functions, e.g. growth, biofilm formation, and expression of virulence factors in S. epidermidis. Two conserved domains, i.e. HATPase_c and REC domains, are found in all 16 pairs of two-component proteins. Homologous modelling analysis indicates that there are similar HATPase_c domain structures of histidine kinases and 13 similar REC domain structures of response regulators, and there is one AMP-PNP binding pocket in the HATPase_c domain and three active aspartate residues in the REC domain. Preliminary experiment reveals that the bioinformatics analysis of the conserved domain structures in the two-component regulatory systems in S. epidermidis may provide useful information for discovery of potential drug target. |
| WOS关键词 | SIGNAL-TRANSDUCTION SYSTEMS ; COAGULASE-NEGATIVE STAPHYLOCOCCI ; BACILLUS-SUBTILIS ; STREPTOCOCCUS-PNEUMONIAE ; NMR STRUCTURE ; SWISS-MODEL ; AUREUS ; INHIBITORS ; IDENTIFICATION ; EXPRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000223586500013 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274068]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Zhong, Y |
| 作者单位 | 1.Fudan Univ, Sch Med, Minist Educ, Shanghai 200032, Peoples R China 2.Fudan Univ, Sch Med, Hlth Key lab Med Mol Virol, Shanghai 200032, Peoples R China 3.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Biodivers Sci & Ecol Engn, Shanghai 200433, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Studies, Bioinformat Ctr, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, ZQ,Zhong, Y,Zhang, J,et al. Bioinformatics analysis of two-component regulatory systems in Staphylococcus epidermidis[J]. CHINESE SCIENCE BULLETIN,2004,49(12):1267-1271. |
| APA | Qin, ZQ.,Zhong, Y.,Zhang, J.,He, YY.,Wu, Y.,...&Qu, D.(2004).Bioinformatics analysis of two-component regulatory systems in Staphylococcus epidermidis.CHINESE SCIENCE BULLETIN,49(12),1267-1271. |
| MLA | Qin, ZQ,et al."Bioinformatics analysis of two-component regulatory systems in Staphylococcus epidermidis".CHINESE SCIENCE BULLETIN 49.12(2004):1267-1271. |
入库方式： OAI收割
来源：上海药物研究所
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