Differential regulation of resveratrol on lipopolysacchride-stimulated human macrophages with or without IFN-gamma pre-priming
文献类型：期刊论文
| 作者 | Feng, YH; Zhu, YN; Liu, J ; Ren, YX; Xu, JY; Yang, YF; Li, XY; Zou, JP
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| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2004-06 |
| 卷号 | 4期号:6页码:713-720 |
| 关键词 | resveratrol PMA-differentiated THP-1 cell CD14 interferon gamma lipopolysaccharide |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2004.02.006 |
| 文献子类 | Article |
| 英文摘要 | Resveratrol, a polyphenol compound found in grapes and red wines, is a prominent anti-cancer agent. In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages. Expression of CD86 on macrophages was enhanced by resveratrol alone and with LPS. When macrophages were primed with IFN-gamma, resveratrol suppressed the expression of HLA-ABC, HLA-DR, CD80, CD86 and inhibited production of TNF-alpha, IL-12, IL-6 and IL-1beta induced by LPS. The differential impact of resveratrol on expression of CD14 might be correlated with differential response of macrophages to LPS with or without IFN-gamma priming. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS关键词 | MONOCYTIC LEUKEMIA-CELLS ; NF-KAPPA-B ; CANCER CELLS ; APOPTOSIS ; ACTIVATION ; RELEASE ; PROLIFERATION ; EXPRESSION ; PROTEIN ; THP-1 |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000221683700002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274070]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Zou, JP |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, YH,Zhu, YN,Liu, J,et al. Differential regulation of resveratrol on lipopolysacchride-stimulated human macrophages with or without IFN-gamma pre-priming[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2004,4(6):713-720. |
| APA | Feng, YH.,Zhu, YN.,Liu, J.,Ren, YX.,Xu, JY.,...&Zou, JP.(2004).Differential regulation of resveratrol on lipopolysacchride-stimulated human macrophages with or without IFN-gamma pre-priming.INTERNATIONAL IMMUNOPHARMACOLOGY,4(6),713-720. |
| MLA | Feng, YH,et al."Differential regulation of resveratrol on lipopolysacchride-stimulated human macrophages with or without IFN-gamma pre-priming".INTERNATIONAL IMMUNOPHARMACOLOGY 4.6(2004):713-720. |
入库方式： OAI收割
来源：上海药物研究所
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