Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats
文献类型：期刊论文
| 作者 | Liang, YQ; Tang, XC
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2004-05-06 |
| 卷号 | 361期号:1-3页码:56-59 |
| 关键词 | huperzine A donepezil rivastigmine acetylcholine acetylcholinesterase Alzheimer's disease rat |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2003.12.071 |
| 文献子类 | Article |
| 英文摘要 | The cholinesterase inhibitors huperzine A, donepezil and rivastigmine were compared for their effects on extracellular acetylcholine concentration and acetylcholinesterase activity in the rat cortex. After i.p. injection, huperzine A (0.25-0.75 mumol/kg), donepezil (2-6 mumol/kg) and rivastigmine (0.75-1.5 mumol/kg) dose-dependently elevated the concentration of acetylcholine. The duration of huperzine A was longest. The time courses of cortical acetylcholinesterase inhibition with middle doses of these agents mirrored the increases of acetylcholine at the same doses. However, acetylcholinesterase inhibition was disproportionately greater after middle dose of rivastigmine than doses of huperzine A and donepezil that increased acetylcholine to a similar extent. Muscle fasciculation appeared only after donepezil with a dose-dependent incidence and intensity. In molar terms, huperzine A was 8- and 2-fold more potent than donepezil and rivastigmine, respectively, in increasing cortical acetylcholine levels, with a longer-lasting effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | EXTRACELLULAR ACETYLCHOLINE ; CHOLINESTERASE-INHIBITORS ; ALZHEIMERS-DISEASE ; IN-VIVO ; 2ND-GENERATION ; QUANTITATION ; HIPPOCAMPUS ; CORTEX ; E2020 ; DRUG |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000221566100016 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274080]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, YQ,Tang, XC. Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats[J]. NEUROSCIENCE LETTERS,2004,361(1-3):56-59. |
| APA | Liang, YQ,&Tang, XC.(2004).Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.NEUROSCIENCE LETTERS,361(1-3),56-59. |
| MLA | Liang, YQ,et al."Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats".NEUROSCIENCE LETTERS 361.1-3(2004):56-59. |
入库方式： OAI收割
来源：上海药物研究所
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