Feitai attenuates bleomycin-induced pulmonary fibrosis in rats
文献类型：期刊论文
| 作者 | Gong, LK ; Li, XH; Wang, H; Zhang, L; Cai, Y; Qi, XM; Liu, LL; Liu, YZ; Wu, XF; Chen, FP
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| 刊名 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2004-05 |
| 卷号 | 27期号:5页码:634-640 |
| 关键词 | Feitai pulmonary fibrosis bleomycin rat |
| ISSN号 | 0918-6158 |
| DOI | 10.1248/bpb.27.634 |
| 文献子类 | Article |
| 英文摘要 | Pulmonary fibrosis is a common consequence of numerous pulmonary diseases. The current therapeutic approaches for this condition are unsatisfactory. Feitai, a composite formula consisting of several herbs, is used in China as a folk remedy for treating patients with pulmonary tuberculosis. In this study, we extensively investigate the effects and mechanisms of Feitai on bleomycin (BLM)-induced pulmonary fibrosis in rats. One hundred and twenty male Sprague-Dawley rats were randomly divided into four groups, referred to as the saline-water, saline-Feitai, BLM-water, and BLM-Feitai groups. Following a single instillation of BLM (5 mg/kg) or saline, rats were orally administered Feitai at a dose of 3 g/kg body weight or sterilized distilled water once daily. Rats were killed at 7, 14, or 28 d post-BLM. Inflammatory cell count, protein concentration, and lactate dehydrogenase activity in bronchoalveolar lavage fluid were measured, and myeloperoxidase activity and lipid peroxide content in lung homogenates were analyzed. Treatment with Feitai inhibited lung fibrotic progression induced by BLM, as indicated by the decrease in lung hydroproline content and lung fibrosis score at 28 d post-BLM. This was accompanied by significant amelioration of BLM-induced body weight loss, lung edema, and inflammatory response during the development of lung injury in the acute phase. The results strongly indicate the beneficial effects of Feitai in protecting against BLM-induced pulmonary fibrosis. Furthermore, the inflammatory response and lipid peroxidation were inhibited by Feitai, suggesting that the effect of this formula on BLM-induced lung injury and fibrosis is associated with antiinflammatory and antioxidant properties. |
| WOS关键词 | INDUCED LUNG FIBROSIS ; N-ACETYLCYSTEINE ; GROWTH-FACTOR ; MICE ; INJURY ; PATHOGENESIS ; SUPEROXIDE ; SURFACTANT ; TOXICITY ; DAMAGE |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000221161200008 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274082]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ren, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Shanghai Pulm Hosp, Shanghai 200043, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, LK,Li, XH,Wang, H,et al. Feitai attenuates bleomycin-induced pulmonary fibrosis in rats[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2004,27(5):634-640. |
| APA | Gong, LK.,Li, XH.,Wang, H.,Zhang, L.,Cai, Y.,...&Ren, J.(2004).Feitai attenuates bleomycin-induced pulmonary fibrosis in rats.BIOLOGICAL & PHARMACEUTICAL BULLETIN,27(5),634-640. |
| MLA | Gong, LK,et al."Feitai attenuates bleomycin-induced pulmonary fibrosis in rats".BIOLOGICAL & PHARMACEUTICAL BULLETIN 27.5(2004):634-640. |
入库方式： OAI收割
来源：上海药物研究所
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