Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells
文献类型：期刊论文
| 作者 | Zhang, HY ; Yan, H; Tang, XC
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2004-04-22 |
| 卷号 | 360期号:1-2页码:21-24 |
| 关键词 | huperzine A beta-amyloid secretory amyloid precursor protein protein kinase C |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2004.01.055 |
| 文献子类 | Article |
| 英文摘要 | We examined whether huperzine A (HupA), a promising therapeutic agent for Alzheimer's disease, could alter the processing of amyloid precursor protein (APP) in rats with P-amyloid protein-(1-40) (Abeta(1-40)) infusion into the cerebral ventricle and in human embryonic kidney 293 (HEK293sw) cells. Daily intraperitoneal administration of HupA for 12 consecutive days produced significant reversals of the Abeta(1-40)-induced down-regulation of secretory APP (APPs) and protein kinase C (PKC) in rats. In the HEK293sw cells, the level of APPs was increased significantly with HupA treatment, and there was a similar change in PKCalpha level under the same condition. However, no significant alternations in the levels of PKCdelta and PKCepsilon were found after HupA treatment. These findings suggest that HupA may affect the processing of APP by up-regulating PKC, especially PKCalpha. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | BETA-PEPTIDE ; CHOLINESTERASE-INHIBITORS ; ALZHEIMERS-DISEASE ; BRAIN CORTEX ; DEGENERATION ; ACTIVATION ; IMPAIRMENT ; APPS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000221080500006 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274090]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, HY,Yan, H,Tang, XC. Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells[J]. NEUROSCIENCE LETTERS,2004,360(1-2):21-24. |
| APA | Zhang, HY,Yan, H,&Tang, XC.(2004).Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells.NEUROSCIENCE LETTERS,360(1-2),21-24. |
| MLA | Zhang, HY,et al."Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells".NEUROSCIENCE LETTERS 360.1-2(2004):21-24. |
入库方式： OAI收割
来源：上海药物研究所
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