BmTx3B, a novel scorpion toxin from Buthus martensi Karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons
文献类型：期刊论文
| 作者 | Li, MH; Wang, YF; Chen, XQ; Zhang, NX ; Wu, HM; Hu, GY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2003-10 |
| 卷号 | 24期号:10页码:1016-1020 |
| 关键词 | BmTx3B Buthus martensi Karsch hippocampus potassium channels scorpion venom |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To examine the effect of BmTx3B, a novel short-chain peptide isolated from the venom of Asian scorpion Buthus martensi Karsch, on voltage-gated potassium channels. METHODS: Two types of voltage-dependent potassium currents were recorded from dissociated hippocampal neurons of neonatal rat in whole-cell voltage-clamp mode, and separated based upon their kinetic properties. RESULTS: BmTx3B (10-100 mumol/L) selectively inhibited the delayed rectifier potassium current (I-K), without affecting the fast transient potassium current (I-A). The inhibition of the peptide on I-K was reversible, concentration-dependent and voltage-independent. BmTx3B did not affect the steady-state activation and inactivation kinetics of the current. CONCLUSION: The short-chain scorpion peptide BmTx3B selectively blocked the delayed rectifier potassium channel. |
| WOS关键词 | SHAKER K+ CHANNEL ; VENOM ; PEPTIDE ; CA1 ; CHARYBDOTOXIN ; RESIDUES ; ACT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1271557 |
| WOS记录号 | WOS:000185749400011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274171]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, GY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bio Organ & Nat Prod Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, MH,Wang, YF,Chen, XQ,et al. BmTx3B, a novel scorpion toxin from Buthus martensi Karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons[J]. ACTA PHARMACOLOGICA SINICA,2003,24(10):1016-1020. |
| APA | Li, MH,Wang, YF,Chen, XQ,Zhang, NX,Wu, HM,&Hu, GY.(2003).BmTx3B, a novel scorpion toxin from Buthus martensi Karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons.ACTA PHARMACOLOGICA SINICA,24(10),1016-1020. |
| MLA | Li, MH,et al."BmTx3B, a novel scorpion toxin from Buthus martensi Karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons".ACTA PHARMACOLOGICA SINICA 24.10(2003):1016-1020. |
入库方式： OAI收割
来源：上海药物研究所
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