BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium currents in rat hippocampal, neurons in vitro
文献类型：期刊论文
| 作者 | Li, MH; Zhang, NX ; Chen, XQ; Wu, G; Wu, HM; Hu, GY
|
| 刊名 | TOXICON
 |
| 出版日期 | 2003-08 |
| 卷号 | 42期号:2页码:199-205 |
| 关键词 | BmKK4 Buthus martensi Karsch hippocampus neurotoxin potassium channel scorpion |
| ISSN号 | 0041-0101 |
| DOI | 10.1016/S0041-0101(03)00136-3 |
| 文献子类 | Article |
| 英文摘要 | A novel short-chain peptide BmKK4 was isolated from the venom of Asian scorpion Buthus martensi Karsch. It is composed of 30 amino acids including six cysteine residues, and shares less than 25% sequence identity with the known alpha-KTx toxins. The action of BmKK4 on voltage-dependent potassium currents was examined in acutely dissociated hippocampal neurons of rat. BmKK4 (10-100 muM) inhibited both the delayed rectifier and fast transient potassium current in concentration-dependent manners. The inhibition was reversible and voltage-independent. BmKK4 caused a depolarizing shift (about 10 mV) of the steady-state activation curve of the currents, without changing their steady-state inactivation behavior. The unique amino acid sequence and clectrophysiological effects suggest that BmKK4 represent a new subfamily of potassium channel toxins. (C) 2003 Elsevier Ltd. All rights reserved. |
| WOS关键词 | K+ CHANNELS ; PEPTIDES ; ACT ; CA1 |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000184754100009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274205]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, GY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, MH,Zhang, NX,Chen, XQ,et al. BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium currents in rat hippocampal, neurons in vitro[J]. TOXICON,2003,42(2):199-205. |
| APA | Li, MH,Zhang, NX,Chen, XQ,Wu, G,Wu, HM,&Hu, GY.(2003).BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium currents in rat hippocampal, neurons in vitro.TOXICON,42(2),199-205. |
| MLA | Li, MH,et al."BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium currents in rat hippocampal, neurons in vitro".TOXICON 42.2(2003):199-205. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。