Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons
文献类型：期刊论文
| 作者 | Zhang, HY ; Tang, XC
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2003-04-10 |
| 卷号 | 340期号:2页码:91-94 |
| 关键词 | huperzine A cholinesterase inhibitor primary rat cortical neurons staurosporine apoptosis Bcl-2 Bax caspase-3 |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(03)00023-5 |
| 文献子类 | Article |
| 英文摘要 | The effects of huperzine A (HupA) on staurosporine-induced neuronal apoptosis and potential mechanisms were investigated in primary cultured rat cortical neurons. Pretreatment of the cells with HupA (0.1-100 muM) 2 h prior to 0.5 muM staurosporine exposure for 24 h, markedly elevated cell survival. Incubation with HupA at higher dose (1 muM) also reduced the DNA fragmentation caused by staurosporine. This dose of HupA also reduced the upregulation of the pro-apoptotic gene, bax, downregulation of the anti-apoptotic gene, bcl-2, and antagonized the decrease in immunoreactive caspase-3 proenzyme. These results demonstrated that HupA protect neurons against staurosporine-induced apoptosis via regulating the apoptotic related genes and caspase-3 proenzyme. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | ALZHEIMERS-DISEASE ; CELL-DEATH ; BCL-X ; APOPTOSIS ; PREVENTION ; PC12 ; DNA |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000182094700005 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274243]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, HY,Tang, XC. Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons[J]. NEUROSCIENCE LETTERS,2003,340(2):91-94. |
| APA | Zhang, HY,&Tang, XC.(2003).Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.NEUROSCIENCE LETTERS,340(2),91-94. |
| MLA | Zhang, HY,et al."Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons".NEUROSCIENCE LETTERS 340.2(2003):91-94. |
入库方式： OAI收割
来源：上海药物研究所
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