Acute effects of huperzine A and tacrine on rat liver
文献类型：期刊论文
| 作者 | Ma, XC; Xin, J; Wang, HX; Zhang, T; Tu, ZH |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2003-03 |
| 卷号 | 24期号:3页码:247-250 |
| 关键词 | cholinesterase inhibitors huperzine A tacrine liver acute toxicity test |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To observe the acute effects of huperzine A and tacrine on rat liver. METHODS: Changes of liver coefficient, serum biochemistry, and histopathology were detected after single dose. In vitro cytotoxicity was assessed by determining extracellular and intracellular amount of lactate dehydrogenase in cultured hepatocytes. RESULTS: Both huperzine A and tacrine raised liver coefficient and increased serum aspartate aminotransferase and alanine aminotransferase. Tacrine induced liver histopathologic changes. The acute effects of huperzine A on liver could be redressed by atropine, while effects of tacrine on liver could not. Concentration-dependent in vitro cytotoxicity occurred with tacrine, but not with huperzine A. CONCLUSION: The acute effects of huperzine A on rat liver are not related to hepatotoxicity. The acute effects of tacrine on rat liver are related to hepatotoxicity. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1271236 |
| WOS记录号 | WOS:000181439200010 |
| 出版者 | SHANGHAI INST MATERIA MEDICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274255]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tu, ZH |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, XC,Xin, J,Wang, HX,et al. Acute effects of huperzine A and tacrine on rat liver[J]. ACTA PHARMACOLOGICA SINICA,2003,24(3):247-250. |
| APA | Ma, XC,Xin, J,Wang, HX,Zhang, T,&Tu, ZH.(2003).Acute effects of huperzine A and tacrine on rat liver.ACTA PHARMACOLOGICA SINICA,24(3),247-250. |
| MLA | Ma, XC,et al."Acute effects of huperzine A and tacrine on rat liver".ACTA PHARMACOLOGICA SINICA 24.3(2003):247-250. |
入库方式： OAI收割
来源：上海药物研究所
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