Protein phosphatase 2A: Its structure, function and activity regulation
文献类型：期刊论文
| 作者 | Liu, WJ; Shen, Y; Ding, J
|
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2003-02 |
| 卷号 | 35期号:2页码:105-112 |
| 关键词 | protein phosphatase 2A(PP2A) holoenzyme complex core dimer enzyme |
| ISSN号 | 0582-9879 |
| 文献子类 | Review |
| 英文摘要 | Protein phosphatase 2A ( PP2A) is a major kind of serine/threonine protein phosphatase in eukaryotic cells. PP2A has many subunits and isozymes encoded by different genes to form many different PP2A holo-enzymes. PP2A play important roles in regulation of cell cycle, signal transduction, cell differentiation, and transformation. Its activity is related to several diseases, including neurodegenerative diseases and cancer. The regulation of PP2A activity is accomplished by its subunits' expression, cellular localization, phosphorylation and methylation. The second messenger, ceramide, also plays an important role in the regulation of PP2A activity, as well as a plenty of low molecular mass inhibitors of PP2A and other protein phosphatases. |
| WOS关键词 | CATALYTIC SUBUNIT ; BCL2 PHOSPHORYLATION ; SIGNAL-TRANSDUCTION ; DNA-REPLICATION ; C-ALPHA ; BINDING ; FAMILY ; CANCER ; PP2A ; DEPHOSPHORYLATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 中文 |
| WOS记录号 | WOS:000181245500001 |
| 出版者 | SHANGHAI INST BIOCHEMISTRY, ACADEMIA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274265]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Div Anti Tumor Pharmacol, State Key Lab Drug Res,Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, WJ,Shen, Y,Ding, J. Protein phosphatase 2A: Its structure, function and activity regulation[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(2):105-112. |
| APA | Liu, WJ,Shen, Y,&Ding, J.(2003).Protein phosphatase 2A: Its structure, function and activity regulation.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(2),105-112. |
| MLA | Liu, WJ,et al."Protein phosphatase 2A: Its structure, function and activity regulation".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.2(2003):105-112. |
入库方式： OAI收割
来源：上海药物研究所
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