Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABA(A) receptor antagonist in rat brain
文献类型：期刊论文
| 作者 | Zhao, XY; Wang, Y; Li, Y ; Chen, XQ; Yang, HH; Yue, JM; Hu, GY
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2003-01-30 |
| 卷号 | 337期号:1页码:33-36 |
| 关键词 | Aconitum gamma-aminobutyric acid diterpenoid alkaloid gamma-aminobutyric acid(A) receptor hippocampus [H-3]Muscimol songorine |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(02)01299-5 |
| 文献子类 | Article |
| 英文摘要 | Songorine, a diterpenoid alkaloid isolated from the genus Aconitum, was recently found to enhance the excitatory synaptic transmission in rat hippocampus. The mechanism underlying the effects was examined in the present study. The alkaloid at 0.1-300 muM inhibited the specific binding of [H-3]muscimol to Triton-treated synaptic membranes of rat brain in a concentration-dependent manner (IC50 = 7.06 muM; 95% confidence limits: 3.28-10.84 muM). Scatchard analysis and Lineweaver-Burk double reciprocal plot of [H-3]muscimol saturation binding data indicate a non-competitive inhibition of the alkaloid on the gamma-aminobutyric acid(A) (GABA(A)) receptor. In acutely dissociated rat hippocampal neurons the alkaloid did not elicit current response, but markedly inhibited the GABA-induced inward current (IC50 = 19.6 muM). The results suggest that songorine is a novel non-competitive antagonist at the GABA(A) receptor in rat brain. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | CA1 PYRAMIDAL CELLS ; HIPPOCAMPAL SLICES ; NEURONAL-ACTIVITY ; DOPAMINE ; EXCITABILITY ; INHIBITION ; INVITRO |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000180756000009 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274270]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, GY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, XY,Wang, Y,Li, Y,et al. Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABA(A) receptor antagonist in rat brain[J]. NEUROSCIENCE LETTERS,2003,337(1):33-36. |
| APA | Zhao, XY.,Wang, Y.,Li, Y.,Chen, XQ.,Yang, HH.,...&Hu, GY.(2003).Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABA(A) receptor antagonist in rat brain.NEUROSCIENCE LETTERS,337(1),33-36. |
| MLA | Zhao, XY,et al."Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABA(A) receptor antagonist in rat brain".NEUROSCIENCE LETTERS 337.1(2003):33-36. |
入库方式： OAI收割
来源：上海药物研究所
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