Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential
文献类型：期刊论文
| 作者 | Tan, WF; Lin, LP; Li, MH; Zhang, YX; Tong, YG; Xiao, D; Ding, J
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| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2003-01-17 |
| 卷号 | 459期号:2-3页码:255-262 |
| 关键词 | quercetin angiogenesis umbilical vein endothelial cell (Human) microvascular dermal endothelial cell (Human) matrix metalloproteinase-2 |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(02)02848-0 |
| 文献子类 | Article |
| 英文摘要 | Quercetin, a dietary-derived flavonoid, suppresses tumor growth in vitro and in vivo, and inhibits the activity of tyrosine kinase. The effects of quercetin on the angiogenic process were examined in this study. Quercetin was found to inhibit several important steps of angiogenesis including proliferation, migration, and tube formation of human microvascular dermal enclothelial cells in a dose-dependent manner. Additionally, the effect of quercetin on endothelial cell proliferation was confirmed using human umbilical vein endothelial cells. The activity of quercetin on the proliferation of endothelial cells was stronger than that on A549, BEL-7402, MKN-45 tumor cells and NIH-3T3 fibroblast cells. The chicken chorioallantoic membrane assay revealed that addition of quercetin displayed an antiangiogenic effect in vivo. After exposure to quercetin. a decrease in the expression and activity of matrix metalloproteinase-2, which is involved in the angiogenic process of migration, invasion, and tube formation, was observed by reverse transcription-polymerase chain reaction (RT-PCR) and gelatin zymography. These findings suggest that quercetin has antiangiogenic potential and that this effect may be related to an influence on the expression and activity of matrix metalloproteinase-2. (C) 2002 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | SQUAMOUS-CELL CARCINOMA ; ESTROGEN-BINDING-SITES ; FACTOR-KAPPA-B ; IN-VITRO ; INHIBITS ANGIOGENESIS ; ENDOTHELIAL-CELLS ; GASTRIC-CANCER ; TUMOR-GROWTH ; PROGRESSION ; EXPRESSION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000180502000019 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274272]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, J |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Div Antitumor Pharmacol, State Key Lab Drug Res,Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, WF,Lin, LP,Li, MH,et al. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2003,459(2-3):255-262. |
| APA | Tan, WF.,Lin, LP.,Li, MH.,Zhang, YX.,Tong, YG.,...&Ding, J.(2003).Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.EUROPEAN JOURNAL OF PHARMACOLOGY,459(2-3),255-262. |
| MLA | Tan, WF,et al."Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential".EUROPEAN JOURNAL OF PHARMACOLOGY 459.2-3(2003):255-262. |
入库方式： OAI收割
来源：上海药物研究所
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