Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia
文献类型：期刊论文
| 作者 | Wang, LS; Zhou, J; Shao, XM; Tang, XC
|
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2002-09-13 |
| 卷号 | 949期号:1-2页码:162-170 |
| 关键词 | huperzine A cholinesterase inhibitor hypoxia-ischeinia Morris water maze CA1 neuron neonatal rat |
| ISSN号 | 0006-8993 |
| DOI | 10.1016/S0006-8993(02)02977-3 |
| 文献子类 | Article |
| 英文摘要 | The protective effects of huperzine A, a novel acetylcholinesterase inhibitor, on hypoxic-ischemc (111) brain injury were investigated in neonatal rats. A unilateral HI brain injury was produced by the ligation of left common carotid artery followed by I h hypoxia with 7.7% oxygen in 7-day-old rat pups. After 5 weeks, HI brain injury in rat pups resulted in working memory impairments shown by increased escape latency in a water maze and reduced time spent in the target quadrant. The combination of common carotid artery ligation and exposure to a hypoxic environment caused the damage in the striatum, cortex, and hippocampus in the ipsilateral hemisphere, and the neuronal loss in the CA1 region. Huperzine A was administrated daily at the dose of 0.05 or 0.1 mg/ kg i.p. for 5 weeks after HI injury. The significant protection against HI injury on behavior and neuropathology was produced by huperzine A at the dose of 0.1 mg/kg. These findings suggest that huperzine A might be beneficial in the treatment of hypoxic-ischemic encephalopathy in neonates. (C) 2002 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | PC12 CELLS ; MEMORY ; PROTECTS ; DAMAGE ; HIPPOCAMPAL ; PERFORMANCE ; IMPAIRMENT ; TACRINE |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000178316900019 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274328]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Fudan Univ, Childrens Hosp, Dept Pediat, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, LS,Zhou, J,Shao, XM,et al. Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia[J]. BRAIN RESEARCH,2002,949(1-2):162-170. |
| APA | Wang, LS,Zhou, J,Shao, XM,&Tang, XC.(2002).Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia.BRAIN RESEARCH,949(1-2),162-170. |
| MLA | Wang, LS,et al."Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia".BRAIN RESEARCH 949.1-2(2002):162-170. |
入库方式： OAI收割
来源：上海药物研究所
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