Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons
文献类型：期刊论文
| 作者 | Li, Y ; Hu, GY
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2002-08-30 |
| 卷号 | 329期号:2页码:153-156 |
| 关键词 | Alzheimer's disease cholinesterase inhibitor hippocampus huperzine A sustained potassium current tacrine |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(02)00620-1 |
| 文献子类 | Article |
| 英文摘要 | The actions of huperzine A (HupA), a novel cholinesterase inhibitor, on the sustained potassium current were investigated in acutely dissociated hippocampal neurons of rat. HupA inhibited the current (IC50 = 856 +/- 1 muM) with voltage-dependency. The effect was insensitive to 3 muM atropine. Tacrine (IC50 = 43 +/- 3 muM) was 20 times more potent than HupA. HupA hyperpolarized the activation curve of the current by 16 mV, and markedly prolonged the decay time constant tau(2). HupA affected neither the steady-state inactivation of the current, nor its recovery from inactivation. The potential relevance of the inhibitory effect of HupA on the current to the treatment of Alzheimer's disease is discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | PYRAMIDAL NEURONS ; CHANNELS ; TACRINE ; CA1 |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000177828500008 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274337]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 信息中心 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Hu, GY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Y,Hu, GY. Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons[J]. NEUROSCIENCE LETTERS,2002,329(2):153-156. |
| APA | Li, Y,&Hu, GY.(2002).Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons.NEUROSCIENCE LETTERS,329(2),153-156. |
| MLA | Li, Y,et al."Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons".NEUROSCIENCE LETTERS 329.2(2002):153-156. |
入库方式： OAI收割
来源：上海药物研究所
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