Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys
文献类型：期刊论文
| 作者 | Ou, LY; Tang, XC ; Cai, JX
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2001-12-21 |
| 卷号 | 433期号:2-3页码:151-156 |
| 关键词 | catecholamine huperzine A working memory reserpine yohimbine (monkey) |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(01)01500-X |
| 文献子类 | Article |
| 英文摘要 | The effect of huperzine A, a reversible and selective acetylcholinesterase inhibitor, on reserpine- or yohimbine-induced spatial working memory deficits in monkeys has been examined using the delayed response task that depends on the integrity of prefrontal cortex. Reserpine (0.1 mg/kg, i.m.) or yohimbine (0.01 mg/kg, i.m.) led to significant impairments in the monkeys' ability to perform the delayed response task. Huperzine A (0.01 mg/kg, i.m. in reserpine-treated monkeys; 0.01-0.1 mg/kg, i.m, in yohimbine-treated monkeys) significantly improved the reserpine- or yohimbine-induced memory impairments. The effect of huperzine A on memory impairments exhibited an inverted U-shaped dose-response pattern. Our data suggest that huperzine A may improve working memory via an adrenergic mechanism. (C) 2001 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | EXPERIMENTAL COGNITIVE IMPAIRMENT ; RADIAL MAZE PERFORMANCE ; ALZHEIMERS-DISEASE ; AGED MONKEYS ; ACETYLCHOLINESTERASE INHIBITOR ; CHOLINERGIC SYSTEM ; IMPROVES MEMORY ; AGONIST ; RATS ; SCOPOLAMINE |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000172991400003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274418]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Cai, JX |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Brain & Behav Sect, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ou, LY,Tang, XC,Cai, JX. Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2001,433(2-3):151-156. |
| APA | Ou, LY,Tang, XC,&Cai, JX.(2001).Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.EUROPEAN JOURNAL OF PHARMACOLOGY,433(2-3),151-156. |
| MLA | Ou, LY,et al."Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys".EUROPEAN JOURNAL OF PHARMACOLOGY 433.2-3(2001):151-156. |
入库方式： OAI收割
来源：上海药物研究所
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