Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils
文献类型：期刊论文
| 作者 | Zhou, J; Zhang, HY ; Tang, XC
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2001-11-09 |
| 卷号 | 313期号:3页码:137-140 |
| 关键词 | huperzine A cholinesterase inhibitor global ischemia Morris water maze hippocampus gerbil |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(01)02265-0 |
| 文献子类 | Article |
| 英文摘要 | The protective effects of huperzine A on transient global ischemia in gerbils were investigated. Five min of global ischemia in gerbils results in working memory impairments shown by increased escape latency in a water maze and reduced time spent in the target quadrant:. These signs of dysfunction are accompanied by delayed degeneration of pyramidal hippocampal CA1 neurons and by decrease in acetylcholinesterase activity in the hippocampus. Subchronic oral administration of huperzineA(0.1 mg/kg,twice per day for 14 days) after ischemia significantly reduced the memory impairment, reduced neuronal degeneration in the CA1 region, and partially restored hippocampal choline acetyltransferase activity. The ability of huperzine A to attenuate memory deficits and neuronal damage after ischemia might be beneficial in cerebrovascular type dementia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | LIPID-PEROXIDATION ; NMDA RECEPTOR ; RAT ; DEATH ; DEMENTIA ; CHOLINE |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000172056000007 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274429]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 上海中药现代化研究中心 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, J,Zhang, HY,Tang, XC. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils[J]. NEUROSCIENCE LETTERS,2001,313(3):137-140. |
| APA | Zhou, J,Zhang, HY,&Tang, XC.(2001).Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.NEUROSCIENCE LETTERS,313(3),137-140. |
| MLA | Zhou, J,et al."Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils".NEUROSCIENCE LETTERS 313.3(2001):137-140. |
入库方式： OAI收割
来源：上海药物研究所
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