Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation
文献类型：期刊论文
| 作者 | Zhou, J; Fu, Y; Tang, XC
|
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2001-07-20 |
| 卷号 | 12期号:10页码:2073-2077 |
| 关键词 | apoptosis apoptosis-related genes huperzine A oxygen-glucose deprivation PC12 cells |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/00001756-200107200-00007 |
| 文献子类 | Article |
| 英文摘要 | The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation. nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p53, bcl-2 and box mRNA after OGD indicated that these genes played important roles in apoptosis. Pre-incubation of the cells for 2 h with 1 muM HupA significantly attenuated apoptosis. The same treatment also reduced the up-regulation of c-jun and box as well as the down-regulation of bcl-2. These data suggest the ability of HupA to attenuate apoptosis induced by OGD may result from its capability to alter the expression of apoptosis-related genes. NeuroReport 12:2073-2077 (C) 2001 Lippincott Williams & Wilkins. |
| WOS关键词 | PC12 CELLS ; CEREBRAL-ISCHEMIA ; DEATH ; APOPTOSIS ; BCL-2 ; NEURONS ; BAX ; MECHANISM ; NECROSIS ; INJURY |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000169809200008 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274469]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, J,Fu, Y,Tang, XC. Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation[J]. NEUROREPORT,2001,12(10):2073-2077. |
| APA | Zhou, J,Fu, Y,&Tang, XC.(2001).Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation.NEUROREPORT,12(10),2073-2077. |
| MLA | Zhou, J,et al."Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation".NEUROREPORT 12.10(2001):2073-2077. |
入库方式： OAI收割
来源：上海药物研究所
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