Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity
文献类型：期刊论文
| 作者 | Sun, HZ; Wu, SF; Tu, ZH |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2001-06 |
| 卷号 | 11期号:2页码:107-115 |
| 关键词 | IGF-IR signaling autocrine drug resistance apoptosis transitional cell carcinoma |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/sj.cr.7290075 |
| 文献子类 | Article |
| 英文摘要 | A major problem which is poorly understood in the management of bladder cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection. Insulin-like growth factor 1 receptor (IGF-1R) signaling plays a very important role in progression, invasion and metastasis of bladder cancer cells. In this study, we investigated whether IGF-1R was involved in the growth stimulating activity and drug resistance of bladder cancer cells. The results showed: The mRNAs of IGF-1, IGF-2 and IGF-1R were strongly expressed in serum-free cultured T24 cell line, whereas normal urothelial cells did not express these factors/receptors or only in trace levels; T24 cell responded far better to growth stimulation by IGF-1 than did normal urothelial cells; blockage of IGF1R by antisense oligodeoxynucleotide (ODN) significantly inhibited the growth of T24 cell and enhanced sensitivity and apoptosis of T24 cells to mitomycin (MMC). These results suggested that blockage of IGF-IR signaling might potentially contribute to the treatment of bladder cancer cells which are insensitive to chemotherapy. |
| WOS关键词 | RESISTANCE-ASSOCIATED PROTEIN ; EPIDERMAL GROWTH-FACTOR ; AUTOCRINE GROWTH ; INDUCED APOPTOSIS ; FACTOR RECEPTOR ; TUMOR-CELLS ; I RECEPTOR ; CARCINOMA ; LINES ; EXPRESSION |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| CSCD记录号 | CSCD:805752 |
| WOS记录号 | WOS:000169787000005 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274489]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tu, ZH |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel |
| 推荐引用方式 GB/T 7714 | Sun, HZ,Wu, SF,Tu, ZH. Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity[J]. CELL RESEARCH,2001,11(2):107-115. |
| APA | Sun, HZ,Wu, SF,&Tu, ZH.(2001).Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity.CELL RESEARCH,11(2),107-115. |
| MLA | Sun, HZ,et al."Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity".CELL RESEARCH 11.2(2001):107-115. |
入库方式： OAI收割
来源：上海药物研究所
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