Similar potency of the enantiomers of huperzine A in inhibition of [H-3]dizocilpine (MK-801) binding in rat cerebral cortex
文献类型：期刊论文
| 作者 | Zhang, YH; Chen, XQ; Yang, HH; Jin, GY; Bai, DL ; Hu, GY
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2000-12-08 |
| 卷号 | 295期号:3页码:116-118 |
| 关键词 | huperzine A cholinesterase inhibitor Alzheimer's disease enantiomers [H-3]dizocilpine (MK-801) binding N-methyl-D-aspartate receptor |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(00)01615-3 |
| 文献子类 | Article |
| 英文摘要 | The inhibition of huperzine A, a potential therapeutic agent to treat Alzheimer's disease, on rat cortical acetylcholinesterase was found to be highly stereospecific. In the present study the effect of the enantiomers of huperzine A on [H-3]dizocilpine (MK-801) binding to synaptic membrane of rat cerebral cortex was compared. The natural (-)-huperzine A and the synthetic (+)-huperzine A inhibited the specific binding of [H-3]MK-801 with a similar potency. The IC50 values were:65 +/- 7 and 82 +/- 12 muM (n = 5 for each enantiomer, P = 0.248), respectively. The result indicates that huperzine A inhibits N-methyl-D-aspartate (NM DA) receptor in rat cerebral cortex without stereoselectivity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | DEMENTIA |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000165658500012 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274547]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, GY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, YH,Chen, XQ,Yang, HH,et al. Similar potency of the enantiomers of huperzine A in inhibition of [H-3]dizocilpine (MK-801) binding in rat cerebral cortex[J]. NEUROSCIENCE LETTERS,2000,295(3):116-118. |
| APA | Zhang, YH,Chen, XQ,Yang, HH,Jin, GY,Bai, DL,&Hu, GY.(2000).Similar potency of the enantiomers of huperzine A in inhibition of [H-3]dizocilpine (MK-801) binding in rat cerebral cortex.NEUROSCIENCE LETTERS,295(3),116-118. |
| MLA | Zhang, YH,et al."Similar potency of the enantiomers of huperzine A in inhibition of [H-3]dizocilpine (MK-801) binding in rat cerebral cortex".NEUROSCIENCE LETTERS 295.3(2000):116-118. |
入库方式： OAI收割
来源：上海药物研究所
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