Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl
文献类型：期刊论文
| 作者 | Li, YM; Han, ZH; Jiang, SH; Jiang, Y ; Yao, SD; Zhu, DY
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-12 |
| 卷号 | 21期号:12页码:1125-1128 |
| 关键词 | Scrophularia ningpoensis Hemsl glycosides antioxidants deoxyadenine nucleotides deoxyguanine nucleotides |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To investigate the antioxidative activity of the constituents of the roots of Scrophularia ningpoensis (Chinese name: Xuanshen). MEHTODS: The main compounds from the roots of Scrophularia ningpoensis were isolated and identified by chromatography and FABMS, NMR etc. Using the techniques of pulse radiolysis, the electron transfers from iridoid glycosides (IG) or phenylpropanoid glycosides (PG) to oxidized OH radical adducts of 2'-deoxyadenosine-5'-monophosphate acid (dAMP) or 2'-deoxyguanosine-5'-monophosphate acid (dGMP) were observed. RESULTS: Two IG: harpagoside and harpagide, two PG: angoroside C and acteoside were obtained as the main hydrophilic constituents of the plant. At 0.1 mmol/L concentration, angoroside C and acteoside were able to repair the oxidized OH adducts dAMP and dGMP significantly. However, harpagoside and harpagide had no such effect. The electron transfer rate constants of angoroside C with dAMP and dGMP were 4.2 x 10(8) and 10.3 x 10(8) L . mol(-1) . s(-1); the electron transfer rate constants of acteoside with dAMP and dGMP were 5.3 x 10(8) and 20.2 x 10(8) L. mol(-1) . s(-1). CONCLUSION: PG from Scrophularia ningpoensis have a potent antioxidative activity for reducting of the oxidized OH adducts of dAMP and dGMP. |
| WOS关键词 | PULSE-RADIOLYSIS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000165828500011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274549]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Zhu, DY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YM,Han, ZH,Jiang, SH,et al. Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl[J]. ACTA PHARMACOLOGICA SINICA,2000,21(12):1125-1128. |
| APA | Li, YM,Han, ZH,Jiang, SH,Jiang, Y,Yao, SD,&Zhu, DY.(2000).Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl.ACTA PHARMACOLOGICA SINICA,21(12),1125-1128. |
| MLA | Li, YM,et al."Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl".ACTA PHARMACOLOGICA SINICA 21.12(2000):1125-1128. |
入库方式： OAI收割
来源：上海药物研究所
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