Moclobemide-induced gynecomastia in rats
文献类型：期刊论文
| 作者 | Ma, XC; Wang, Y; Liu, JH; Tu, ZH |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-10 |
| 卷号 | 21期号:10页码:893-896 |
| 关键词 | moclobemide toxicity gynecomastia prolactin prolactin receptors rat |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the toxic effect of moclobemide on male breast and to elucidate its mechanism of action. METHODS: Routine histopathological analysis was used to diagnose the effect of moclobemide on male breast in mts. Plasma concentrations of estrogen, androgen, and prolactin were measured by a ratioimmunometer and relative receptors of mammary gland tissue were detected immunohistochemically. RESULTS: After 180-d moclobemide treatment, the presence of gynecomastia was 0, 5, 5, 7/10 rats in 0, 60, 240, and 600 mg/kg groups, respectively. After 30-d convalescence, only one rat in 600 mg/kg group got the incidence of gynecomastia. Serum prolactin concentration had a trend to decrease with increasing dose and prolactin receptors in mammary gland were up-regulated. CONCLUSION: Long-term treatment with moclobemide causes gynecomastia in rats, which is reversible. The mechanism of moclobemide-induced gynecomastia may be related to the increase in prolactin receptors in mammary glands. |
| WOS关键词 | A INHIBITOR MOCLOBEMIDE ; LONG-TERM TREATMENT ; MALE BREAST ; SECRETION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000089725800005 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274568]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tu, ZH |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, XC,Wang, Y,Liu, JH,et al. Moclobemide-induced gynecomastia in rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(10):893-896. |
| APA | Ma, XC,Wang, Y,Liu, JH,&Tu, ZH.(2000).Moclobemide-induced gynecomastia in rats.ACTA PHARMACOLOGICA SINICA,21(10),893-896. |
| MLA | Ma, XC,et al."Moclobemide-induced gynecomastia in rats".ACTA PHARMACOLOGICA SINICA 21.10(2000):893-896. |
入库方式： OAI收割
来源：上海药物研究所
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