Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells
文献类型：期刊论文
| 作者 | Zhang, HY ; Tang, XC
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2000-09-29 |
| 卷号 | 292期号:1页码:41-44 |
| 关键词 | huperzine B cholinesterase inhibitor free radicals hydrogen peroxide glutathione peroxidase catalase PC12 cells malondialdehyde |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(00)01433-6 |
| 文献子类 | Article |
| 英文摘要 | A number of studies indicate that free radicals are involved in the neurodegeneration in Alzheimer's disease (AD). The present study was mainly conducted to examine the effect of Huperzine B on H2O2 induced toxicity in rat pheochromocytoma line PC12 by measuring cell lesion, level of lipid peroxidation and antioxidant enzyme activities. Following a 30 min exposure of the cells to H2O2 (150 mu M), a marked decrease in cell survival, activities of glutathione peroxidase and catalase as well as increased production of malondialdehyde (MDA) were found. Pretreatment of the cells with huperzine B (10-100 mu M) prior to H2O2 exposure significantly elevated the cell survival, antioxidant enzyme activities and decreased the level of MDA. The above-mentioned neuroprotective effects are also observed with tacrine (1 mu M), donepezil (10 mu M) and galanthamine (10 mu M), suggesting that the neuroprotective effects of cholinesterase inhibitor might partly contribute to the clinical efficacy in AD treatment. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | NERVE GROWTH-FACTOR ; CHOLINESTERASE-INHIBITORS ; ALZHEIMERS-DISEASE ; STIMULATION ; RECEPTORS ; TOXICITY ; BINDING |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000089528900011 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274578]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, HY,Tang, XC. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells[J]. NEUROSCIENCE LETTERS,2000,292(1):41-44. |
| APA | Zhang, HY,&Tang, XC.(2000).Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells.NEUROSCIENCE LETTERS,292(1),41-44. |
| MLA | Zhang, HY,et al."Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells".NEUROSCIENCE LETTERS 292.1(2000):41-44. |
入库方式： OAI收割
来源：上海药物研究所
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