Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
文献类型：期刊论文
| 作者 | Wang, LM; Han, YF; Tang, XC
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2000-06-09 |
| 卷号 | 398期号:1页码:65-72 |
| 关键词 | (-)-huperzine A acetylcholinesterase cholinesterase inhibitor cerebral ischemia Morris water maze learning memory free radical Alzheimer's disease |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(00)00291-0 |
| 文献子类 | Article |
| 英文摘要 | The effects of (-)-huperzine A, a promising therapeutic agent for Alzheimer's disease. on learning behavior and on alterations of the cholinergic system, the oxygen free radicals and energy metabolites induced by permanent bilateral Ligation of the common carotid arteries were investigated in rats. Daily oral administration of huperzine A produced a significant improvement of the deficit in the learning of the water maze task, beginning 28 days after ischemia, correlating to about 33-40% inhibition of acetyl-cholinesterase activity in cortex and hippocampus. Huperzine A significantly restored the decrease in choline acetyltransferase activity in hippocampus and significantly reduced the increases in superoxide dismutase, lipid peroxide, lactate and glucose to their normal levels. The present findings demonstrate that the improvement by huperzine A of the cognitive dysfunction in the late phase in chronically hypoperfused rats is due to its effects, not only on the cholinergic system, but also on the oxygen free radical system and energy metabolism. Out results strongly suggest that huperzine A has therapeutic potential for the treatment of dementia caused by cholinergic dysfunction and/or decrease of cerebral blood flow. (C) 2000 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | VASCULAR DEMENTIA ; ENERGY-METABOLISM ; WISTAR RATS ; AGED RATS ; BRAIN ; ACETYLCHOLINE ; DYSFUNCTION ; OCCLUSION ; GLUTAMATE ; ISCHEMIA |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000087674500008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274607]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, LM,Han, YF,Tang, XC. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2000,398(1):65-72. |
| APA | Wang, LM,Han, YF,&Tang, XC.(2000).Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,398(1),65-72. |
| MLA | Wang, LM,et al."Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 398.1(2000):65-72. |
入库方式： OAI收割
来源：上海药物研究所
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