Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance
文献类型：期刊论文
| 作者 | Ye, JW; Shang, YZ; Wang, ZM; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-01 |
| 卷号 | 21期号:1页码:65-69 |
| 关键词 | huperzine A cholinesterase inhibitors aging maze learning scopolamine |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM To determine the memory-improving properties of huperzine A in aged rats with memory impairments naturally occurring or induced by scopolamine. METHODS: Morris water maze was used to investigate the effects of huperzine A on the acquisition and memory impairments. RESULTS: During 7-day acquisition trials, aged rats took longer latency to find the platform. Huperzine A (0.1-0.2 mg/kg, sc) could significantly reduce the latency. In the probe trials on the eighth day, huperzine A (0.1, 0.2 and 0.4 mg/ kg, sc) significantly increased the time in the quadrant where plateform had disappeared in aged rats. In the acute experiment, scopolamine (0.1 mg/kg, ip) significantly impaired spatial memory in the trained aged rats. Huperzine A (0.4 mg/kg, sc) significantly reversed the memory deficits induced by scopolamine. CONCLUSION: Huperzine A ameliorates the impaired memory naturally occurring or induced by scopolamine in aged rats. |
| WOS关键词 | ALZHEIMERS-DISEASE ; CHOLINERGIC SYSTEM ; IN-VITRO ; DEFICITS ; TACRINE ; E2020 |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000084710700010 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274654]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Dept Biomed Engn, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, JW,Shang, YZ,Wang, ZM,et al. Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance[J]. ACTA PHARMACOLOGICA SINICA,2000,21(1):65-69. |
| APA | Ye, JW,Shang, YZ,Wang, ZM,&Tang, XC.(2000).Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance.ACTA PHARMACOLOGICA SINICA,21(1),65-69. |
| MLA | Ye, JW,et al."Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance".ACTA PHARMACOLOGICA SINICA 21.1(2000):65-69. |
入库方式： OAI收割
来源：上海药物研究所
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