Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury
文献类型：期刊论文
| 作者 | Xiao, XQ; Yang, JW; Tang, XC
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 1999-11-12 |
| 卷号 | 275期号:2页码:73-76 |
| 关键词 | Huperzine A acetylcholinesterase inhibitor free radicals hydrogen peroxide glutathione peroxidase catalase PC12 cells malondialdehyde |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(99)00695-3 |
| 文献子类 | Article |
| 英文摘要 | The effects of Huperzine A (HupA), a novel acetylcholinesterase inhibitor, on hydrogen peroxide (H2O2) induced cell lesion, level of lipid peroxidation and antioxidant enzyme activities were investigated in rat pheochromocytoma line PC12. Following a 6-h exposure of the cells to H2O2 (200 mu M), a marked reduction in cell survival and activities of glutathione peroxidase and catalase, as well as increased production of malondialdehyde (MDA) were observed. Pretreatment of the cells with HupA (0.1-10.0 mu M) prior to H2O2 exposure significantly elevated the cell survival and antioxidant enzyme activities and decreased the level of MDA. Our results indicated that in addition to its anticholinesterase effects, HupA had protective effects against free radical-induced cell toxicity, which might be beneficial for the treatment of Alzheimer's disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | AMYLOID-BETA-PROTEIN ; NERVE GROWTH-FACTOR ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; MEMORY |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000083628400001 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274676]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, XQ,Yang, JW,Tang, XC. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury[J]. NEUROSCIENCE LETTERS,1999,275(2):73-76. |
| APA | Xiao, XQ,Yang, JW,&Tang, XC.(1999).Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury.NEUROSCIENCE LETTERS,275(2),73-76. |
| MLA | Xiao, XQ,et al."Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury".NEUROSCIENCE LETTERS 275.2(1999):73-76. |
入库方式： OAI收割
来源：上海药物研究所
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