Action sites of rotation and unit firing induced by l-stepholidine and DA agonists in basal ganglia of 6-OHDA-lesioned rats
文献类型：期刊论文
| 作者 | Zhang, XX ; Liu, J; Fu, Y; Hu, GY; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-11 |
| 卷号 | 20期号:11页码:979-986 |
| 关键词 | stepholidine rotation basal ganglia kainic acid oxidopamine dopamine agonists 6-hydroxydopamine apomorphine substantia nigra globus pallidus |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To elucidate the action sites of l-stepholidine (SPD) in the basal ganglia. METHODS: Counting the rotations after intra-nucleus microinjection and recording the neuron firing by microiontophoresis of SPD and DA agonists in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned rats. RESULTS: The DA immunoreactive substance was markedly reduced in the 6-OHDA-lesioned rats. The intra-neostriatum microinjection of apomorphine (Apo, D-1/D-2), SK&F 38393 (D-1), and SPD elicited remarkable rotation,and the characteristics of SK&F 38393-produced rotation were of long latency and long duration. The intra-substantia nigra pars reticulata (SNR) injection of Ape, SK&F 38393,and SPD induced the rotation response, while the selective D-2 agonist quinpirole hydrochloride (Ly171555) did not because df scarce D-2 receptors in the SNR. The intraglobus pallidus (CP) injection of DA agonists and SPD failed to evoke rotation, but the GP nucleus still had the contribution to rotation elicited by ip injection of DA agonists and SPD in the 6-OHDA-lesioned rats with successive kainic acid (KA) lesion. Besides, the successive lesion of entopeduncular nucleus (EP) on rotation was less important than that of GP nucleus. The microiontophoresis of Apo and SPD into the SNR could evoke the neuron firing, but failed to activate the GP neurons, which were activated by sodium glutamate (Glu) and inhibited by gamma-aminobutyric acid (GABA). CONCLUSION: The action sites of SPD-induced rotation and neuron firing via the D-1 receptors are in the neostriatum and SNR instead of GP. The direct neurocircuit through SNR is the most important for rotation of 6-OHDA-lesioned rats. |
| WOS关键词 | DOPAMINE-RECEPTORS ; INTRANIGRAL INJECTIONS ; BEHAVIOR ; TETRAHYDROPROTOBERBERINES ; ANTAGONIST ; D-1 |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000083583700004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274679]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Jin, GZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XX,Liu, J,Fu, Y,et al. Action sites of rotation and unit firing induced by l-stepholidine and DA agonists in basal ganglia of 6-OHDA-lesioned rats[J]. ACTA PHARMACOLOGICA SINICA,1999,20(11):979-986. |
| APA | Zhang, XX,Liu, J,Fu, Y,Hu, GY,&Jin, GZ.(1999).Action sites of rotation and unit firing induced by l-stepholidine and DA agonists in basal ganglia of 6-OHDA-lesioned rats.ACTA PHARMACOLOGICA SINICA,20(11),979-986. |
| MLA | Zhang, XX,et al."Action sites of rotation and unit firing induced by l-stepholidine and DA agonists in basal ganglia of 6-OHDA-lesioned rats".ACTA PHARMACOLOGICA SINICA 20.11(1999):979-986. |
入库方式： OAI收割
来源：上海药物研究所
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