Comparison of the effects of cholinesterase inhibitors on [H-3]MK-801 binding in rat cerebral cortex
文献类型：期刊论文
| 作者 | Wang, XD; Chen, XQ; Yang, HH; Hu, GY |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 1999-09-03 |
| 卷号 | 272期号:1页码:21-24 |
| 关键词 | huperzine A huperzine B tacrine physostigmine donepezil galanthamine [H-3]MK-801 binding N-methyl-D-aspartate receptor |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(99)00567-4 |
| 文献子类 | Article |
| 英文摘要 | Huperzine A, a selective inhibitor of acetylcholinesterase, was recently demonstrated to exert an antagonist effect on N-methyl-D-aspartate (NMDA) receptor in rat cerebral cortex. In the present study, the effects of six cholinesterase inhibitors, e.g, huperzine A, huperzine B, tacrine, donepezil (E2020), physostigmine and galanthamine on [H-3]dizocilpine (MK-801) binding to synaptic membrane of rat cerebral cortex were compared. Their IC50 values (mean +/- SD) were 36.9 +/- 12.1, 316.8 +/- 93.2, 33.2 +/- 3.7, 135.0 +/- 15.1, 50.4 +/- 7.4, and 3344 +/- 295 mu M, respectively. The rank order of potency is tacrine approximate to huperzine A > physostigmine > donepezil > huperzine B >> galanthamine. There is no correlation between their activities to inhibit [H-3]MK-801 binding and to inhibit acetylcholinesterase (r = +0.563, P = 0.245). The results suggest that most cholinesterase inhibitors available exhibit an antagonist effect on NMDA receptor in rat cerebral cortex in addition to their inhibitory effect on acetylcholinesterase. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | HUPERZINE-A ; ALZHEIMERS-DISEASE ; SITE |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000082693500006 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274697]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, GY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, XD,Chen, XQ,Yang, HH,et al. Comparison of the effects of cholinesterase inhibitors on [H-3]MK-801 binding in rat cerebral cortex[J]. NEUROSCIENCE LETTERS,1999,272(1):21-24. |
| APA | Wang, XD,Chen, XQ,Yang, HH,&Hu, GY.(1999).Comparison of the effects of cholinesterase inhibitors on [H-3]MK-801 binding in rat cerebral cortex.NEUROSCIENCE LETTERS,272(1),21-24. |
| MLA | Wang, XD,et al."Comparison of the effects of cholinesterase inhibitors on [H-3]MK-801 binding in rat cerebral cortex".NEUROSCIENCE LETTERS 272.1(1999):21-24. |
入库方式： OAI收割
来源：上海药物研究所
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